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TM239_HUMAN
ID   TM239_HUMAN             Reviewed;         195 AA.
AC   Q8WW34; Q5JY54; Q6ZU23;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-FEB-2014, sequence version 3.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Transmembrane protein 239;
GN   Name=TMEM239;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q8WW34; P17544: ATF7; NbExp=3; IntAct=EBI-9675724, EBI-765623;
CC       Q8WW34; Q8NI60: COQ8A; NbExp=5; IntAct=EBI-9675724, EBI-745535;
CC       Q8WW34; Q7Z6J4: FGD2; NbExp=3; IntAct=EBI-9675724, EBI-1057190;
CC       Q8WW34; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-9675724, EBI-726510;
CC       Q8WW34; Q9HB07: MYG1; NbExp=3; IntAct=EBI-9675724, EBI-709754;
CC       Q8WW34; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-9675724, EBI-741158;
CC       Q8WW34; Q9UNA4: POLI; NbExp=3; IntAct=EBI-9675724, EBI-741774;
CC       Q8WW34; O00560: SDCBP; NbExp=3; IntAct=EBI-9675724, EBI-727004;
CC       Q8WW34; Q9HC62: SENP2; NbExp=3; IntAct=EBI-9675724, EBI-714881;
CC       Q8WW34; P45974: USP5; NbExp=3; IntAct=EBI-9675724, EBI-741277;
CC       Q8WW34-2; Q13520: AQP6; NbExp=3; IntAct=EBI-11528917, EBI-13059134;
CC       Q8WW34-2; P11912: CD79A; NbExp=3; IntAct=EBI-11528917, EBI-7797864;
CC       Q8WW34-2; P56880: CLDN20; NbExp=3; IntAct=EBI-11528917, EBI-23801559;
CC       Q8WW34-2; P58418: CLRN1; NbExp=3; IntAct=EBI-11528917, EBI-17274839;
CC       Q8WW34-2; Q8NI60: COQ8A; NbExp=3; IntAct=EBI-11528917, EBI-745535;
CC       Q8WW34-2; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-11528917, EBI-6942903;
CC       Q8WW34-2; Q68CJ9: CREB3L3; NbExp=3; IntAct=EBI-11528917, EBI-852194;
CC       Q8WW34-2; Q6PI48: DARS2; NbExp=3; IntAct=EBI-11528917, EBI-3917045;
CC       Q8WW34-2; Q96GG9: DCUN1D1; NbExp=3; IntAct=EBI-11528917, EBI-740086;
CC       Q8WW34-2; Q15125: EBP; NbExp=3; IntAct=EBI-11528917, EBI-3915253;
CC       Q8WW34-2; P54849: EMP1; NbExp=3; IntAct=EBI-11528917, EBI-4319440;
CC       Q8WW34-2; Q8TBP5: FAM174A; NbExp=3; IntAct=EBI-11528917, EBI-18636064;
CC       Q8WW34-2; Q6PCT2-2: FBXL19; NbExp=3; IntAct=EBI-11528917, EBI-11959077;
CC       Q8WW34-2; O15552: FFAR2; NbExp=3; IntAct=EBI-11528917, EBI-2833872;
CC       Q8WW34-2; Q9Y680: FKBP7; NbExp=3; IntAct=EBI-11528917, EBI-3918971;
CC       Q8WW34-2; Q9BXU8: FTHL17; NbExp=3; IntAct=EBI-11528917, EBI-12156897;
CC       Q8WW34-2; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-11528917, EBI-713304;
CC       Q8WW34-2; P48165: GJA8; NbExp=3; IntAct=EBI-11528917, EBI-17458373;
CC       Q8WW34-2; Q96P66: GPR101; NbExp=3; IntAct=EBI-11528917, EBI-17935713;
CC       Q8WW34-2; Q8TDV0: GPR151; NbExp=3; IntAct=EBI-11528917, EBI-11955647;
CC       Q8WW34-2; O15529: GPR42; NbExp=3; IntAct=EBI-11528917, EBI-18076404;
CC       Q8WW34-2; P42858: HTT; NbExp=3; IntAct=EBI-11528917, EBI-466029;
CC       Q8WW34-2; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-11528917, EBI-739832;
CC       Q8WW34-2; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-11528917, EBI-373355;
CC       Q8WW34-2; Q96C03-3: MIEF2; NbExp=3; IntAct=EBI-11528917, EBI-11988931;
CC       Q8WW34-2; Q00013: MPP1; NbExp=3; IntAct=EBI-11528917, EBI-711788;
CC       Q8WW34-2; Q96HJ5: MS4A3; NbExp=3; IntAct=EBI-11528917, EBI-12806656;
CC       Q8WW34-2; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-11528917, EBI-3923617;
CC       Q8WW34-2; Q8N3F0: MTURN; NbExp=3; IntAct=EBI-11528917, EBI-11980301;
CC       Q8WW34-2; Q9NX40: OCIAD1; NbExp=3; IntAct=EBI-11528917, EBI-2683029;
CC       Q8WW34-2; Q2M2E3: ODF4; NbExp=3; IntAct=EBI-11528917, EBI-12382569;
CC       Q8WW34-2; Q96BN8: OTULIN; NbExp=3; IntAct=EBI-11528917, EBI-750730;
CC       Q8WW34-2; Q9BQ51: PDCD1LG2; NbExp=3; IntAct=EBI-11528917, EBI-16427978;
CC       Q8WW34-2; Q96T60: PNKP; NbExp=3; IntAct=EBI-11528917, EBI-1045072;
CC       Q8WW34-2; Q9BRK0: REEP2; NbExp=3; IntAct=EBI-11528917, EBI-11337973;
CC       Q8WW34-2; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-11528917, EBI-10192441;
CC       Q8WW34-2; A8MRB1: S100B; NbExp=3; IntAct=EBI-11528917, EBI-16432654;
CC       Q8WW34-2; P57086: SCAND1; NbExp=3; IntAct=EBI-11528917, EBI-745846;
CC       Q8WW34-2; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-11528917, EBI-17247926;
CC       Q8WW34-2; O00560: SDCBP; NbExp=3; IntAct=EBI-11528917, EBI-727004;
CC       Q8WW34-2; Q9HC62: SENP2; NbExp=3; IntAct=EBI-11528917, EBI-714881;
CC       Q8WW34-2; Q14973: SLC10A1; NbExp=3; IntAct=EBI-11528917, EBI-3923031;
CC       Q8WW34-2; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-11528917, EBI-18159983;
CC       Q8WW34-2; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-11528917, EBI-17595455;
CC       Q8WW34-2; O95436-2: SLC34A2; NbExp=3; IntAct=EBI-11528917, EBI-12811757;
CC       Q8WW34-2; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-11528917, EBI-17295964;
CC       Q8WW34-2; Q13596: SNX1; NbExp=3; IntAct=EBI-11528917, EBI-2822329;
CC       Q8WW34-2; O60749: SNX2; NbExp=3; IntAct=EBI-11528917, EBI-1046690;
CC       Q8WW34-2; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-11528917, EBI-742688;
CC       Q8WW34-2; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-11528917, EBI-17280858;
CC       Q8WW34-2; Q17RD7: SYT16; NbExp=3; IntAct=EBI-11528917, EBI-10238936;
CC       Q8WW34-2; Q969Z0: TBRG4; NbExp=3; IntAct=EBI-11528917, EBI-702328;
CC       Q8WW34-2; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-11528917, EBI-6268651;
CC       Q8WW34-2; Q9NWD8: TMEM248; NbExp=3; IntAct=EBI-11528917, EBI-10314986;
CC       Q8WW34-2; Q9Y320: TMX2; NbExp=3; IntAct=EBI-11528917, EBI-6447886;
CC       Q8WW34-2; P34981: TRHR; NbExp=3; IntAct=EBI-11528917, EBI-18055230;
CC       Q8WW34-2; P57075-2: UBASH3A; NbExp=3; IntAct=EBI-11528917, EBI-7353612;
CC       Q8WW34-2; P45974-2: USP5; NbExp=3; IntAct=EBI-11528917, EBI-12072186;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8WW34-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8WW34-2; Sequence=VSP_053737;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH21178.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AK126033; BAC86404.1; -; mRNA.
DR   EMBL; AL035460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL161656; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471133; EAX10573.1; -; Genomic_DNA.
DR   EMBL; BC021178; AAH21178.1; ALT_INIT; mRNA.
DR   CCDS; CCDS54444.1; -. [Q8WW34-2]
DR   CCDS; CCDS82595.1; -. [Q8WW34-1]
DR   RefSeq; NP_001161142.1; NM_001167670.2. [Q8WW34-2]
DR   RefSeq; NP_001305136.1; NM_001318207.1. [Q8WW34-1]
DR   RefSeq; XP_011527431.1; XM_011529129.2. [Q8WW34-2]
DR   AlphaFoldDB; Q8WW34; -.
DR   BioGRID; 940453; 70.
DR   IntAct; Q8WW34; 65.
DR   MINT; Q8WW34; -.
DR   iPTMnet; Q8WW34; -.
DR   PhosphoSitePlus; Q8WW34; -.
DR   BioMuta; TMEM239; -.
DR   DMDM; 353558900; -.
DR   MassIVE; Q8WW34; -.
DR   PaxDb; Q8WW34; -.
DR   PeptideAtlas; Q8WW34; -.
DR   PRIDE; Q8WW34; -.
DR   ProteomicsDB; 68307; -.
DR   ProteomicsDB; 74855; -. [Q8WW34-1]
DR   Antibodypedia; 74574; 5 antibodies from 5 providers.
DR   DNASU; 100288797; -.
DR   Ensembl; ENST00000361033.1; ENSP00000354312.1; ENSG00000198326.10. [Q8WW34-1]
DR   Ensembl; ENST00000380585.2; ENSP00000369959.1; ENSG00000198326.10. [Q8WW34-2]
DR   GeneID; 100288797; -.
DR   KEGG; hsa:100288797; -.
DR   MANE-Select; ENST00000380585.2; ENSP00000369959.1; NM_001167670.3; NP_001161142.1. [Q8WW34-2]
DR   UCSC; uc002wgx.3; human. [Q8WW34-1]
DR   CTD; 100288797; -.
DR   DisGeNET; 100288797; -.
DR   GeneCards; TMEM239; -.
DR   HGNC; HGNC:40044; TMEM239.
DR   HPA; ENSG00000198326; Tissue enriched (testis).
DR   neXtProt; NX_Q8WW34; -.
DR   OpenTargets; ENSG00000198326; -.
DR   VEuPathDB; HostDB:ENSG00000198326; -.
DR   eggNOG; ENOG502R18E; Eukaryota.
DR   GeneTree; ENSGT00390000005090; -.
DR   HOGENOM; CLU_125766_0_0_1; -.
DR   InParanoid; Q8WW34; -.
DR   OMA; PQRAVPW; -.
DR   OrthoDB; 1571659at2759; -.
DR   PhylomeDB; Q8WW34; -.
DR   TreeFam; TF337840; -.
DR   PathwayCommons; Q8WW34; -.
DR   SignaLink; Q8WW34; -.
DR   BioGRID-ORCS; 100288797; 10 hits in 1056 CRISPR screens.
DR   GenomeRNAi; 100288797; -.
DR   Pharos; Q8WW34; Tdark.
DR   PRO; PR:Q8WW34; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   RNAct; Q8WW34; protein.
DR   Bgee; ENSG00000198326; Expressed in right testis and 30 other tissues.
DR   Genevisible; Q8WW34; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR031694; TMEM239.
DR   PANTHER; PTHR37356; PTHR37356; 1.
DR   Pfam; PF15841; TMEM239; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..195
FT                   /note="Transmembrane protein 239"
FT                   /id="PRO_0000413694"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..43
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_053737"
SQ   SEQUENCE   195 AA;  21842 MW;  56A1F7799411E2A4 CRC64;
     MRVGTWICLP GRPGRCRKQH DLGNCPEVPG IFKTLALSPG APDMMQQPRV ETDTIGAGEG
     PQQAVPWSAW VTRHGWVRWW VSHMPPSWIQ WWSTSNWRQP LQRLLWGLEG ILYLLLALML
     CHALFTTGSH LLSSLWPVVA AVWRHLLPAL LLLVLSALPA LLFTASFLLL FSTLLSLVGL
     LTSMTHPGDT QDLDQ
 
 
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