TM240_MOUSE
ID TM240_MOUSE Reviewed; 173 AA.
AC B2RWJ3;
DT 04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Transmembrane protein 240;
GN Name=Tmem240; Synonyms=Gm5151;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY, PHOSPHORYLATION AT SER-169, AND
RP SUBCELLULAR LOCATION.
RX PubMed=22645316; DOI=10.1074/mcp.o112.018366;
RA Trinidad J.C., Barkan D.T., Gulledge B.F., Thalhammer A., Sali A.,
RA Schoepfer R., Burlingame A.L.;
RT "Global identification and characterization of both O-GlcNAcylation and
RT phosphorylation at the murine synapse.";
RL Mol. Cell. Proteomics 11:215-229(2012).
CC -!- SUBCELLULAR LOCATION: Synapse {ECO:0000269|PubMed:22645316}. Cell
CC membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
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DR EMBL; AL670236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466594; EDL15027.1; -; Genomic_DNA.
DR EMBL; BC147820; AAI47821.1; -; mRNA.
DR EMBL; BC147826; AAI47827.1; -; mRNA.
DR CCDS; CCDS51403.1; -.
DR RefSeq; NP_001094976.1; NM_001101506.1.
DR AlphaFoldDB; B2RWJ3; -.
DR IntAct; B2RWJ3; 1.
DR STRING; 10090.ENSMUSP00000127341; -.
DR iPTMnet; B2RWJ3; -.
DR PhosphoSitePlus; B2RWJ3; -.
DR PaxDb; B2RWJ3; -.
DR PRIDE; B2RWJ3; -.
DR ProteomicsDB; 259470; -.
DR Antibodypedia; 77999; 39 antibodies from 10 providers.
DR Ensembl; ENSMUST00000127188; ENSMUSP00000127341; ENSMUSG00000084845.
DR Ensembl; ENSMUST00000147721; ENSMUSP00000130974; ENSMUSG00000084845.
DR GeneID; 381582; -.
DR KEGG; mmu:381582; -.
DR UCSC; uc012dqw.1; mouse.
DR CTD; 339453; -.
DR MGI; MGI:3648074; Tmem240.
DR VEuPathDB; HostDB:ENSMUSG00000084845; -.
DR eggNOG; ENOG502QWKH; Eukaryota.
DR GeneTree; ENSGT00400000023987; -.
DR HOGENOM; CLU_145117_0_0_1; -.
DR InParanoid; B2RWJ3; -.
DR OMA; AVACLMD; -.
DR OrthoDB; 1310776at2759; -.
DR PhylomeDB; B2RWJ3; -.
DR BioGRID-ORCS; 381582; 3 hits in 73 CRISPR screens.
DR PRO; PR:B2RWJ3; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; B2RWJ3; protein.
DR Bgee; ENSMUSG00000084845; Expressed in interventricular septum and 47 other tissues.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0097060; C:synaptic membrane; IDA:UniProtKB.
DR InterPro; IPR027947; TMEM240.
DR PANTHER; PTHR28666; PTHR28666; 1.
DR Pfam; PF15207; TMEM240; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Phosphoprotein; Reference proteome; Synapse;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..173
FT /note="Transmembrane protein 240"
FT /id="PRO_0000431907"
FT TRANSMEM 5..25
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT MOD_RES 169
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:22645316"
SQ SEQUENCE 173 AA; 20005 MW; FA1980811EBB4D62 CRC64;
MSMSANTMIF MILGASIVMA IACLMDMNAL LDRFHNYILP HLRGEDRVCH CNCGRHHIHY
VIPYDGDQSV VDASENYFVT DNVTKQEIDL MLGLLLGFCI SWFLVWMDGV LHCAVRAWRA
GRRYDGSWTW LPKLCSLREL GRRPHRPFEE PTGNMVHVKQ KLYHNGHPSP RHL