TM241_HUMAN
ID TM241_HUMAN Reviewed; 296 AA.
AC Q24JQ0; I0J130; Q6ZTS7; Q6ZW41;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Transmembrane protein 241;
GN Name=TMEM241; Synonyms=C18orf45;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Sawaki H., Kwon Y., Narimatsu H.;
RT "Gene encoding similar protein to yeast sugar-nucleotide transporter,
RT Vrg4p.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND VARIANT
RP PHE-131.
RC TISSUE=Fibroblast, and Liver;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP INDUCTION.
RX PubMed=23027870; DOI=10.1074/jbc.m112.405050;
RA Hansen H.G., Schmidt J.D., Soltoft C.L., Ramming T., Geertz-Hansen H.M.,
RA Christensen B., Sorensen E.S., Juncker A.S., Appenzeller-Herzog C.,
RA Ellgaard L.;
RT "Hyperactivity of the Ero1alpha oxidase elicits endoplasmic reticulum
RT stress but no broad antioxidant response.";
RL J. Biol. Chem. 287:39513-39523(2012).
CC -!- INTERACTION:
CC Q24JQ0; O15400: STX7; NbExp=3; IntAct=EBI-18172866, EBI-3221827;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q24JQ0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q24JQ0-2; Sequence=VSP_028706, VSP_028708;
CC Name=3;
CC IsoId=Q24JQ0-3; Sequence=VSP_028704, VSP_028705, VSP_028707;
CC -!- INDUCTION: Up-regulated by inducers of the unfolded protein response
CC (UPR), including tunicamycin and thapsigargin.
CC {ECO:0000269|PubMed:23027870}.
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM241 family. {ECO:0000305}.
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DR EMBL; AB253738; BAM11306.1; -; mRNA.
DR EMBL; AK123623; BAC85665.1; -; mRNA.
DR EMBL; AK126247; BAC86502.1; -; mRNA.
DR EMBL; AC011731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC026634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC114510; AAI14511.1; -; mRNA.
DR EMBL; BC114561; AAI14562.1; -; mRNA.
DR CCDS; CCDS11876.2; -. [Q24JQ0-1]
DR RefSeq; NP_116322.3; NM_032933.5. [Q24JQ0-1]
DR AlphaFoldDB; Q24JQ0; -.
DR SMR; Q24JQ0; -.
DR BioGRID; 124432; 7.
DR IntAct; Q24JQ0; 1.
DR STRING; 9606.ENSP00000372720; -.
DR iPTMnet; Q24JQ0; -.
DR PhosphoSitePlus; Q24JQ0; -.
DR BioMuta; TMEM241; -.
DR DMDM; 121940968; -.
DR PaxDb; Q24JQ0; -.
DR PeptideAtlas; Q24JQ0; -.
DR PRIDE; Q24JQ0; -.
DR Antibodypedia; 54177; 27 antibodies from 12 providers.
DR DNASU; 85019; -.
DR Ensembl; ENST00000383233.8; ENSP00000372720.3; ENSG00000134490.14. [Q24JQ0-1]
DR Ensembl; ENST00000473688.5; ENSP00000431584.1; ENSG00000134490.14. [Q24JQ0-2]
DR Ensembl; ENST00000477053.5; ENSP00000437280.1; ENSG00000134490.14. [Q24JQ0-3]
DR GeneID; 85019; -.
DR KEGG; hsa:85019; -.
DR MANE-Select; ENST00000383233.8; ENSP00000372720.3; NM_032933.6; NP_116322.3.
DR UCSC; uc002kuf.4; human. [Q24JQ0-1]
DR CTD; 85019; -.
DR DisGeNET; 85019; -.
DR GeneCards; TMEM241; -.
DR HGNC; HGNC:31723; TMEM241.
DR HPA; ENSG00000134490; Low tissue specificity.
DR MIM; 615430; gene.
DR neXtProt; NX_Q24JQ0; -.
DR OpenTargets; ENSG00000134490; -.
DR PharmGKB; PA134952915; -.
DR VEuPathDB; HostDB:ENSG00000134490; -.
DR eggNOG; KOG1444; Eukaryota.
DR GeneTree; ENSGT00510000048348; -.
DR HOGENOM; CLU_081157_0_0_1; -.
DR InParanoid; Q24JQ0; -.
DR OMA; WAIIHLF; -.
DR OrthoDB; 1093260at2759; -.
DR PhylomeDB; Q24JQ0; -.
DR TreeFam; TF338291; -.
DR PathwayCommons; Q24JQ0; -.
DR SignaLink; Q24JQ0; -.
DR BioGRID-ORCS; 85019; 11 hits in 1081 CRISPR screens.
DR ChiTaRS; TMEM241; human.
DR GenomeRNAi; 85019; -.
DR Pharos; Q24JQ0; Tdark.
DR PRO; PR:Q24JQ0; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q24JQ0; protein.
DR Bgee; ENSG00000134490; Expressed in buccal mucosa cell and 196 other tissues.
DR ExpressionAtlas; Q24JQ0; baseline and differential.
DR Genevisible; Q24JQ0; HS.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..296
FT /note="Transmembrane protein 241"
FT /id="PRO_0000307316"
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 41..66
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028704"
FT VAR_SEQ 128..149
FT /note="SALLLLAAAGCLPFNDSQFNPD -> RLHLERTRQNQTSRLSSCLKGD (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028705"
FT VAR_SEQ 146..159
FT /note="FNPDGYFWAIIHLL -> GLIKFYRSPRNPVH (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_028706"
FT VAR_SEQ 150..296
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028707"
FT VAR_SEQ 160..296
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_028708"
FT VARIANT 131
FT /note="L -> F (in dbSNP:rs8099409)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_035406"
SQ SEQUENCE 296 AA; 32647 MW; E84189255BCA2A96 CRC64;
MCVRRSLVGL TFCTCYLASY LTNKYVLSVL KFTYPTLFQG WQTLIGGLLL HVSWKLGWVE
INSSSRSHVL VWLPASVLFV GIIYAGSRAL SRLAIPVFLT LHNVAEVIIC GYQKCFQKEK
TSPAKICSAL LLLAAAGCLP FNDSQFNPDG YFWAIIHLLC VGAYKILQKS QKPSALSDID
QQYLNYIFSV VLLAFASHPT GDLFSVLDFP FLYFYRFHGS CCASGFLGFF LMFSTVKLKN
LLAPGQCAAW IFFAKIITAG LSILLFDAIL TSATTGCLLL GALGEALLVF SERKSS
