TM241_MOUSE
ID TM241_MOUSE Reviewed; 297 AA.
AC Q3UME2; Q8BQ16; Q8CAM4; Q8CAM9; Q8CD42;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Transmembrane protein 241;
GN Name=Tmem241;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
RC STRAIN=C57BL/6J;
RC TISSUE=Hypothalamus, Mammary gland, Spinal ganglion, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q3UME2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3UME2-2; Sequence=VSP_028714;
CC Name=3;
CC IsoId=Q3UME2-3; Sequence=VSP_028710, VSP_028713;
CC Name=4;
CC IsoId=Q3UME2-4; Sequence=VSP_028709, VSP_028711, VSP_028712;
CC -!- SIMILARITY: Belongs to the TMEM241 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC30011.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK031517; BAC27431.1; -; mRNA.
DR EMBL; AK038419; BAC29994.1; -; mRNA.
DR EMBL; AK038472; BAC30011.1; ALT_FRAME; mRNA.
DR EMBL; AK051727; BAC34738.1; -; mRNA.
DR EMBL; AK144963; BAE26156.1; -; mRNA.
DR EMBL; BC094382; AAH94382.1; -; mRNA.
DR CCDS; CCDS84358.1; -. [Q3UME2-1]
DR CCDS; CCDS84359.1; -. [Q3UME2-2]
DR RefSeq; NP_001276595.1; NM_001289666.1. [Q3UME2-1]
DR RefSeq; NP_001276596.1; NM_001289667.1.
DR RefSeq; NP_848916.2; NM_178801.5. [Q3UME2-2]
DR AlphaFoldDB; Q3UME2; -.
DR SMR; Q3UME2; -.
DR STRING; 10090.ENSMUSP00000052001; -.
DR PhosphoSitePlus; Q3UME2; -.
DR PaxDb; Q3UME2; -.
DR PRIDE; Q3UME2; -.
DR Antibodypedia; 54177; 27 antibodies from 12 providers.
DR DNASU; 338363; -.
DR Ensembl; ENSMUST00000055447; ENSMUSP00000052001; ENSMUSG00000049411. [Q3UME2-2]
DR Ensembl; ENSMUST00000092075; ENSMUSP00000089709; ENSMUSG00000049411. [Q3UME2-3]
DR Ensembl; ENSMUST00000209859; ENSMUSP00000147687; ENSMUSG00000049411. [Q3UME2-1]
DR Ensembl; ENSMUST00000211298; ENSMUSP00000147954; ENSMUSG00000049411. [Q3UME2-3]
DR GeneID; 338363; -.
DR KEGG; mmu:338363; -.
DR UCSC; uc008ebv.3; mouse. [Q3UME2-1]
DR UCSC; uc008ebw.2; mouse. [Q3UME2-2]
DR UCSC; uc008ebx.2; mouse. [Q3UME2-4]
DR CTD; 85019; -.
DR MGI; MGI:2442435; Tmem241.
DR VEuPathDB; HostDB:ENSMUSG00000049411; -.
DR eggNOG; KOG1444; Eukaryota.
DR GeneTree; ENSGT00510000048348; -.
DR InParanoid; Q3UME2; -.
DR OMA; WAIIHLF; -.
DR OrthoDB; 1093260at2759; -.
DR PhylomeDB; Q3UME2; -.
DR BioGRID-ORCS; 338363; 1 hit in 36 CRISPR screens.
DR ChiTaRS; Tmem241; mouse.
DR PRO; PR:Q3UME2; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q3UME2; protein.
DR Bgee; ENSMUSG00000049411; Expressed in animal zygote and 158 other tissues.
DR ExpressionAtlas; Q3UME2; baseline and differential.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..297
FT /note="Transmembrane protein 241"
FT /id="PRO_0000307317"
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 65
FT /note="P -> PSALSDSARMADHQAPRILLSPQCWDYRCALPHPDSPWVLGILLRSP
FT SLHI (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028709"
FT VAR_SEQ 177..188
FT /note="SDIDQQYLNYIF -> RGPACWGLPLPS (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028710"
FT VAR_SEQ 177
FT /note="S -> R (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028711"
FT VAR_SEQ 178..297
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028712"
FT VAR_SEQ 189..297
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028713"
FT VAR_SEQ 277..297
FT /note="CFLLGGLGEALLVFSERRSSS -> WCQPAG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_028714"
FT CONFLICT 71
FT /note="I -> M (in Ref. 1; BAE26156)"
FT /evidence="ECO:0000305"
FT CONFLICT 85
FT /note="A -> S (in Ref. 1; BAE26156)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 297 AA; 32965 MW; 281824EDAE3196A6 CRC64;
MNVRRSLLGL TFCTCYLASH LTNKYVLSVL KFTYPTLFQG WQTFIGGLLL HMSWKLGWVE
LHSSPRSDVL IWLPASALFV GIIYAGSKAL SRLAVPVFFI LHNVAEVLTC GYQKCVWKEK
TSLSKICSAL FLLAAAGCLP FQDSQFDPDG YFWALIHIFC VGSYKILRKS RKPTVLSDID
QQYLNYIFSM VLLAFASHPT GDLFGALDFP FLYFYRFHGS CCASGVLGFF LMLSTVRLRS
ILAPGQCAAW ILCAKVVTAG LSMLLFDMAL TKATVGCFLL GGLGEALLVF SERRSSS
