TM242_DANRE
ID TM242_DANRE Reviewed; 142 AA.
AC Q4V8S3; Q5SNY1;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Transmembrane protein 242 {ECO:0000250|UniProtKB:Q9NWH2};
GN Name=tmem242 {ECO:0000250|UniProtKB:Q9NWH2}; ORFNames=si:dkey-60a16.5;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Larva;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Scaffold protein that participates in the c-ring assembly of
CC mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by
CC facilitating the membrane insertion and oligomer formation of the
CC subunit c/ATP5MC3. Participates in the incorporation of the c-ring into
CC vestigial complexes. Additionally influences the incorporation of
CC subunits MT-ATP6, MT-ATP8, ATP5MJ, and ATP5MK in the ATP synthase.
CC {ECO:0000250|UniProtKB:Q9NWH2}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9NWH2}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9NWH2}.
CC -!- SIMILARITY: Belongs to the TMEM242 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH97228.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAI11725.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAI21177.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL953887; CAI11725.1; ALT_INIT; Genomic_DNA.
DR EMBL; BX649499; CAI11725.1; JOINED; Genomic_DNA.
DR EMBL; BX649499; CAI21177.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL953887; CAI21177.1; JOINED; Genomic_DNA.
DR EMBL; BC097228; AAH97228.1; ALT_INIT; mRNA.
DR RefSeq; NP_001153486.1; NM_001160014.1.
DR AlphaFoldDB; Q4V8S3; -.
DR STRING; 7955.ENSDARP00000053879; -.
DR PaxDb; Q4V8S3; -.
DR Ensembl; ENSDART00000053880; ENSDARP00000053879; ENSDARG00000037070.
DR GeneID; 569632; -.
DR KEGG; dre:569632; -.
DR CTD; 729515; -.
DR ZFIN; ZDB-GENE-040724-146; tmem242.
DR eggNOG; ENOG502S2GB; Eukaryota.
DR GeneTree; ENSGT00390000008642; -.
DR HOGENOM; CLU_115460_0_0_1; -.
DR InParanoid; Q4V8S3; -.
DR OMA; YAVMGTG; -.
DR OrthoDB; 1365284at2759; -.
DR PhylomeDB; Q4V8S3; -.
DR TreeFam; TF323317; -.
DR PRO; PR:Q4V8S3; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 20.
DR Bgee; ENSDARG00000037070; Expressed in heart and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR009792; TMEM242.
DR PANTHER; PTHR13141; PTHR13141; 1.
DR Pfam; PF07096; DUF1358; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..142
FT /note="Transmembrane protein 242"
FT /id="PRO_0000295851"
FT TOPO_DOM 1..27
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:Q9NWH2"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..77
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:Q9NWH2"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..142
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:Q9NWH2"
FT CONFLICT 44
FT /note="A -> S (in Ref. 2; AAH97228)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 142 AA; 14930 MW; 5EBA939B0D52A93E CRC64;
MSVEQASASG AVSDIVEDDK SHLIKGGAFL ATVATAGMIA GFGATLAVAK KKSPDWFNKG
IIGSAAVPES GASLALRALG WGSLYAWCGV GLLSLTIWKA MGVHSLQEFR QKMQSIFPAI
PKNEDAQANS VPFDWNSIFK SK
