TM242_MOUSE
ID TM242_MOUSE Reviewed; 140 AA.
AC Q8VCR3; Q8C2T2; Q8CEX9; Q9CYJ2; Q9D1H4;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Transmembrane protein 242 {ECO:0000305};
GN Name=Tmem242 {ECO:0000312|MGI:MGI:1917794};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Embryo, Inner ear, Thymus, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Scaffold protein that participates in the c-ring assembly of
CC mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by
CC facilitating the membrane insertion and oligomer formation of the
CC subunit c/ATP5MC3. Participates in the incorporation of the c-ring into
CC vestigial complexes. Additionally influences the incorporation of
CC subunits MT-ATP6, MT-ATP8, ATP5MJ, and ATP5MK in the ATP synthase.
CC {ECO:0000250|UniProtKB:Q9NWH2}.
CC -!- SUBUNIT: Interacts with the core subunits NDUFAF1, ECSIT and ACAD9 of
CC the MCIA complex. Interacts with ATP5MC3, NDUFC2, TMEM70, MT-ND2 AND
CC MT-ND3. {ECO:0000250|UniProtKB:Q9NWH2}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9NWH2}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9NWH2}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8VCR3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8VCR3-2; Sequence=VSP_027110;
CC Name=3;
CC IsoId=Q8VCR3-3; Sequence=VSP_027111, VSP_027112;
CC -!- SIMILARITY: Belongs to the TMEM242 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC25272.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK003559; BAB22856.1; -; mRNA.
DR EMBL; AK009851; BAC25272.1; ALT_FRAME; mRNA.
DR EMBL; AK017626; BAB30845.1; -; mRNA.
DR EMBL; AK088025; BAC40103.1; -; mRNA.
DR EMBL; AK155326; BAE33193.1; -; mRNA.
DR EMBL; AK158107; BAE34359.1; -; mRNA.
DR EMBL; BC019420; AAH19420.1; -; mRNA.
DR CCDS; CCDS49930.1; -. [Q8VCR3-1]
DR RefSeq; NP_081733.3; NM_027457.4. [Q8VCR3-1]
DR AlphaFoldDB; Q8VCR3; -.
DR SMR; Q8VCR3; -.
DR STRING; 10090.ENSMUSP00000005053; -.
DR PhosphoSitePlus; Q8VCR3; -.
DR EPD; Q8VCR3; -.
DR PaxDb; Q8VCR3; -.
DR PeptideAtlas; Q8VCR3; -.
DR PRIDE; Q8VCR3; -.
DR ProteomicsDB; 259414; -. [Q8VCR3-1]
DR ProteomicsDB; 259415; -. [Q8VCR3-2]
DR ProteomicsDB; 259416; -. [Q8VCR3-3]
DR Antibodypedia; 49845; 43 antibodies from 8 providers.
DR DNASU; 70544; -.
DR Ensembl; ENSMUST00000005053; ENSMUSP00000005053; ENSMUSG00000004945. [Q8VCR3-1]
DR Ensembl; ENSMUST00000185896; ENSMUSP00000139712; ENSMUSG00000004945. [Q8VCR3-2]
DR Ensembl; ENSMUST00000188282; ENSMUSP00000139629; ENSMUSG00000004945. [Q8VCR3-3]
DR GeneID; 70544; -.
DR KEGG; mmu:70544; -.
DR UCSC; uc008afa.1; mouse. [Q8VCR3-1]
DR UCSC; uc008afc.1; mouse. [Q8VCR3-3]
DR UCSC; uc008afd.1; mouse. [Q8VCR3-2]
DR CTD; 729515; -.
DR MGI; MGI:1917794; Tmem242.
DR VEuPathDB; HostDB:ENSMUSG00000004945; -.
DR eggNOG; ENOG502S2GB; Eukaryota.
DR GeneTree; ENSGT00390000008642; -.
DR HOGENOM; CLU_115460_0_0_1; -.
DR InParanoid; Q8VCR3; -.
DR OMA; YAVMGTG; -.
DR OrthoDB; 1365284at2759; -.
DR PhylomeDB; Q8VCR3; -.
DR TreeFam; TF323317; -.
DR BioGRID-ORCS; 70544; 10 hits in 74 CRISPR screens.
DR ChiTaRS; Tmem242; mouse.
DR PRO; PR:Q8VCR3; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8VCR3; protein.
DR Bgee; ENSMUSG00000004945; Expressed in hindlimb stylopod muscle and 246 other tissues.
DR Genevisible; Q8VCR3; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISO:MGI.
DR GO; GO:0033615; P:mitochondrial proton-transporting ATP synthase complex assembly; ISO:MGI.
DR InterPro; IPR009792; TMEM242.
DR PANTHER; PTHR13141; PTHR13141; 1.
DR Pfam; PF07096; DUF1358; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Alternative splicing; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..140
FT /note="Transmembrane protein 242"
FT /id="PRO_0000295849"
FT TOPO_DOM 1..28
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:Q9NWH2"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..80
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:Q9NWH2"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..140
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:Q9NWH2"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9NWH2"
FT VAR_SEQ 109..140
FT /note="MKDFRSKMQSIFPPIPKNHESAEEWEEVLKWK -> VSTSPCESCLSTLCCL
FT KFLVFKFAYILVPVF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027110"
FT VAR_SEQ 109..118
FT /note="MKDFRSKMQS -> ALFDCREETR (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027111"
FT VAR_SEQ 119..140
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027112"
FT CONFLICT 18
FT /note="G -> R (in Ref. 1; BAC40103/BAE33193)"
FT /evidence="ECO:0000305"
FT CONFLICT 127
FT /note="H -> R (in Ref. 1; BAC40103/BAE33193)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 140 AA; 14916 MW; AF42EC70C1AED3D8 CRC64;
METSGPGPGE SSELEAPGSP DDRLFLVKGG IFLGSAAAAG MLAGFVTTLS LAKKKSPEWF
NKGTMATAAL PESGSSLALR ALGWGSLYAW CGVGVISFAV WKALGVHSMK DFRSKMQSIF
PPIPKNHESA EEWEEVLKWK
