TM243_HUMAN
ID TM243_HUMAN Reviewed; 118 AA.
AC Q9BU79; A4D1C6; B2R9I4; D6W5P1;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Transmembrane protein 243;
DE AltName: Full=MDR1- and mitochondrial taxol resistance-associated protein {ECO:0000303|PubMed:15556294};
DE Short=MM-TRAG {ECO:0000303|PubMed:15556294};
GN Name=TMEM243; Synonyms=C7orf23;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=15556294; DOI=10.1016/j.gene.2004.06.013;
RA Duan Z., Brakora K.A., Seiden M.V.;
RT "MM-TRAG (MGC4175), a novel intracellular mitochondrial protein, is
RT associated with the taxol- and doxorubicin-resistant phenotype in human
RT cancer cell lines.";
RL Gene 340:53-59(2004).
RN [7]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- INTERACTION:
CC Q9BU79; Q13520: AQP6; NbExp=3; IntAct=EBI-12887458, EBI-13059134;
CC Q9BU79; Q13323: BIK; NbExp=3; IntAct=EBI-12887458, EBI-700794;
CC Q9BU79; P20138: CD33; NbExp=3; IntAct=EBI-12887458, EBI-3906571;
CC Q9BU79; P04233-2: CD74; NbExp=3; IntAct=EBI-12887458, EBI-12222807;
CC Q9BU79; P11912: CD79A; NbExp=3; IntAct=EBI-12887458, EBI-7797864;
CC Q9BU79; Q8N5K1: CISD2; NbExp=3; IntAct=EBI-12887458, EBI-1045797;
CC Q9BU79; Q86T13: CLEC14A; NbExp=3; IntAct=EBI-12887458, EBI-17710733;
CC Q9BU79; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-12887458, EBI-18013275;
CC Q9BU79; Q15125: EBP; NbExp=3; IntAct=EBI-12887458, EBI-3915253;
CC Q9BU79; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-12887458, EBI-18535450;
CC Q9BU79; Q9NYP7: ELOVL5; NbExp=3; IntAct=EBI-12887458, EBI-11037623;
CC Q9BU79; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-12887458, EBI-781551;
CC Q9BU79; Q8TBP5: FAM174A; NbExp=3; IntAct=EBI-12887458, EBI-18636064;
CC Q9BU79; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-12887458, EBI-18304435;
CC Q9BU79; P48165: GJA8; NbExp=3; IntAct=EBI-12887458, EBI-17458373;
CC Q9BU79; Q9NPR9: GPR108; NbExp=3; IntAct=EBI-12887458, EBI-11343451;
CC Q9BU79; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-12887458, EBI-13345167;
CC Q9BU79; O60883: GPR37L1; NbExp=3; IntAct=EBI-12887458, EBI-2927498;
CC Q9BU79; Q8TED1: GPX8; NbExp=3; IntAct=EBI-12887458, EBI-11721746;
CC Q9BU79; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-12887458, EBI-18053395;
CC Q9BU79; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-12887458, EBI-10266796;
CC Q9BU79; P43628: KIR2DL3; NbExp=3; IntAct=EBI-12887458, EBI-8632435;
CC Q9BU79; Q9H400: LIME1; NbExp=3; IntAct=EBI-12887458, EBI-2830566;
CC Q9BU79; Q7Z4F1: LRP10; NbExp=3; IntAct=EBI-12887458, EBI-2830349;
CC Q9BU79; Q6IN84: MRM1; NbExp=3; IntAct=EBI-12887458, EBI-5454865;
CC Q9BU79; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-12887458, EBI-3923617;
CC Q9BU79; P15941-11: MUC1; NbExp=3; IntAct=EBI-12887458, EBI-17263240;
CC Q9BU79; P60201-2: PLP1; NbExp=3; IntAct=EBI-12887458, EBI-12188331;
CC Q9BU79; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-12887458, EBI-10192441;
CC Q9BU79; Q96TC7: RMDN3; NbExp=3; IntAct=EBI-12887458, EBI-1056589;
CC Q9BU79; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-12887458, EBI-3920694;
CC Q9BU79; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-12887458, EBI-17247926;
CC Q9BU79; Q9BY50: SEC11C; NbExp=3; IntAct=EBI-12887458, EBI-2855401;
CC Q9BU79; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-12887458, EBI-17280858;
CC Q9BU79; Q96IK0: TMEM101; NbExp=3; IntAct=EBI-12887458, EBI-3922699;
CC Q9BU79; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-12887458, EBI-8638294;
CC Q9BU79; Q53FP2: TMEM35A; NbExp=3; IntAct=EBI-12887458, EBI-11722971;
CC Q9BU79; Q96B21: TMEM45B; NbExp=3; IntAct=EBI-12887458, EBI-3923061;
CC Q9BU79; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-12887458, EBI-11742770;
CC Q9BU79; O15393-2: TMPRSS2; NbExp=3; IntAct=EBI-12887458, EBI-12345267;
CC Q9BU79; Q5T4F4: ZFYVE27; NbExp=3; IntAct=EBI-12887458, EBI-3892947;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:15556294}.
CC -!- SIMILARITY: Belongs to the TMEM243 family. {ECO:0000305}.
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DR EMBL; BT006973; AAP35619.1; -; mRNA.
DR EMBL; AK313794; BAG36531.1; -; mRNA.
DR EMBL; CH236949; EAL24179.1; -; Genomic_DNA.
DR EMBL; CH471091; EAW76960.1; -; Genomic_DNA.
DR EMBL; CH471091; EAW76961.1; -; Genomic_DNA.
DR EMBL; BC002837; AAH02837.1; -; mRNA.
DR CCDS; CCDS5602.1; -.
DR RefSeq; NP_001316401.1; NM_001329472.1.
DR RefSeq; NP_001316402.1; NM_001329473.1.
DR RefSeq; NP_001316403.1; NM_001329474.1.
DR RefSeq; NP_001316404.1; NM_001329475.1.
DR RefSeq; NP_077291.1; NM_024315.3.
DR AlphaFoldDB; Q9BU79; -.
DR SMR; Q9BU79; -.
DR BioGRID; 122579; 45.
DR IntAct; Q9BU79; 41.
DR STRING; 9606.ENSP00000398083; -.
DR iPTMnet; Q9BU79; -.
DR PhosphoSitePlus; Q9BU79; -.
DR BioMuta; TMEM243; -.
DR DMDM; 38257751; -.
DR EPD; Q9BU79; -.
DR jPOST; Q9BU79; -.
DR MassIVE; Q9BU79; -.
DR MaxQB; Q9BU79; -.
DR PaxDb; Q9BU79; -.
DR PeptideAtlas; Q9BU79; -.
DR PRIDE; Q9BU79; -.
DR ProteomicsDB; 79064; -.
DR TopDownProteomics; Q9BU79; -.
DR Antibodypedia; 15281; 35 antibodies from 10 providers.
DR DNASU; 79161; -.
DR Ensembl; ENST00000257637.8; ENSP00000257637.3; ENSG00000135185.12.
DR Ensembl; ENST00000433078.5; ENSP00000398083.1; ENSG00000135185.12.
DR GeneID; 79161; -.
DR KEGG; hsa:79161; -.
DR MANE-Select; ENST00000257637.8; ENSP00000257637.3; NM_024315.4; NP_077291.1.
DR UCSC; uc003uio.4; human.
DR CTD; 79161; -.
DR DisGeNET; 79161; -.
DR GeneCards; TMEM243; -.
DR HGNC; HGNC:21707; TMEM243.
DR HPA; ENSG00000135185; Low tissue specificity.
DR MIM; 616993; gene.
DR neXtProt; NX_Q9BU79; -.
DR OpenTargets; ENSG00000135185; -.
DR PharmGKB; PA134985688; -.
DR VEuPathDB; HostDB:ENSG00000135185; -.
DR eggNOG; ENOG502RZ1F; Eukaryota.
DR GeneTree; ENSGT00390000010221; -.
DR HOGENOM; CLU_148752_0_0_1; -.
DR InParanoid; Q9BU79; -.
DR OMA; LLLIYWY; -.
DR PhylomeDB; Q9BU79; -.
DR TreeFam; TF329078; -.
DR PathwayCommons; Q9BU79; -.
DR SignaLink; Q9BU79; -.
DR BioGRID-ORCS; 79161; 16 hits in 1083 CRISPR screens.
DR ChiTaRS; TMEM243; human.
DR GenomeRNAi; 79161; -.
DR Pharos; Q9BU79; Tdark.
DR PRO; PR:Q9BU79; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9BU79; protein.
DR Bgee; ENSG00000135185; Expressed in left lobe of thyroid gland and 194 other tissues.
DR ExpressionAtlas; Q9BU79; baseline and differential.
DR Genevisible; Q9BU79; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR022564; DUF2678.
DR PANTHER; PTHR28603; PTHR28603; 1.
DR Pfam; PF10856; DUF2678; 1.
PE 1: Evidence at protein level;
KW Acetylation; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..118
FT /note="Transmembrane protein 243"
FT /id="PRO_0000089579"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22814378"
SQ SEQUENCE 118 AA; 13391 MW; 0809C40610A42760 CRC64;
MEDFATRTYG TSGLDNRPLF GETSAKDRII NLVVGSLTSL LILVTLISAF VFPQLPPKPL
NIFFAVCISL SSITACILIY WYRQGDLEPK FRKLIYYIIF SIIMLCICAN LYFHDVGR
