TM244_HUMAN
ID TM244_HUMAN Reviewed; 128 AA.
AC Q5VVB8;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Transmembrane protein 244;
GN Name=TMEM244; Synonyms=C6orf191;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AL451046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS34536.1; -.
DR RefSeq; NP_001010876.1; NM_001010876.1.
DR AlphaFoldDB; Q5VVB8; -.
DR STRING; 9606.ENSP00000357125; -.
DR BioMuta; TMEM244; -.
DR DMDM; 74747217; -.
DR PaxDb; Q5VVB8; -.
DR PeptideAtlas; Q5VVB8; -.
DR PRIDE; Q5VVB8; -.
DR TopDownProteomics; Q5VVB8; -.
DR Antibodypedia; 50386; 38 antibodies from 7 providers.
DR DNASU; 253582; -.
DR Ensembl; ENST00000368143.6; ENSP00000357125.1; ENSG00000203756.8.
DR Ensembl; ENST00000438392.2; ENSP00000403755.1; ENSG00000203756.8.
DR GeneID; 253582; -.
DR KEGG; hsa:253582; -.
DR MANE-Select; ENST00000368143.6; ENSP00000357125.1; NM_001010876.2; NP_001010876.1.
DR UCSC; uc003qbs.3; human.
DR CTD; 253582; -.
DR GeneCards; TMEM244; -.
DR HGNC; HGNC:21571; TMEM244.
DR HPA; ENSG00000203756; Tissue enriched (retina).
DR neXtProt; NX_Q5VVB8; -.
DR OpenTargets; ENSG00000203756; -.
DR PharmGKB; PA134909151; -.
DR VEuPathDB; HostDB:ENSG00000203756; -.
DR eggNOG; ENOG502RA7Q; Eukaryota.
DR GeneTree; ENSGT00940000154347; -.
DR HOGENOM; CLU_122907_0_0_1; -.
DR InParanoid; Q5VVB8; -.
DR OMA; FPSTEHW; -.
DR OrthoDB; 1583277at2759; -.
DR PhylomeDB; Q5VVB8; -.
DR TreeFam; TF340485; -.
DR PathwayCommons; Q5VVB8; -.
DR SignaLink; Q5VVB8; -.
DR BioGRID-ORCS; 253582; 11 hits in 1027 CRISPR screens.
DR GenomeRNAi; 253582; -.
DR Pharos; Q5VVB8; Tdark.
DR PRO; PR:Q5VVB8; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5VVB8; protein.
DR Bgee; ENSG00000203756; Expressed in pituitary gland and 55 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR019185; Integral_membrane_SYS1-rel.
DR PANTHER; PTHR12952; PTHR12952; 1.
PE 4: Predicted;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..128
FT /note="Transmembrane protein 244"
FT /id="PRO_0000238467"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 60
FT /note="N -> I (in dbSNP:rs7760577)"
FT /id="VAR_033681"
FT VARIANT 80
FT /note="F -> L (in dbSNP:rs4629709)"
FT /id="VAR_026549"
FT VARIANT 86
FT /note="E -> G (in dbSNP:rs9492393)"
FT /id="VAR_026550"
FT VARIANT 111
FT /note="F -> V (in dbSNP:rs7776426)"
FT /id="VAR_026551"
SQ SEQUENCE 128 AA; 14657 MW; 9AB7F28C72185C38 CRC64;
MALQVRVAPS KVVLQKFLLC VILFYTVYYV SLSMGCVMFE VHELNVLAPF DFKTNPSWLN
INYKVLLVST EVTYFVCGLF FVPVVEEWVW DYAISVTILH VAITSTVMLE FPLTSHWWAA
LGISKLLV
