TM245_BOVIN
ID TM245_BOVIN Reviewed; 868 AA.
AC E1BD52;
DT 16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 1.
DT 03-AUG-2022, entry version 50.
DE RecName: Full=Transmembrane protein 245;
GN Name=TMEM245;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86)
CC family. {ECO:0000305}.
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DR EMBL; DAAA02024465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; E1BD52; -.
DR STRING; 9913.ENSBTAP00000047510; -.
DR PaxDb; E1BD52; -.
DR PRIDE; E1BD52; -.
DR eggNOG; KOG2365; Eukaryota.
DR HOGENOM; CLU_005960_0_0_1; -.
DR InParanoid; E1BD52; -.
DR TreeFam; TF315224; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR002549; AI-2E-like.
DR PANTHER; PTHR21716; PTHR21716; 1.
DR Pfam; PF01594; AI-2E_transport; 1.
PE 3: Inferred from homology;
KW Acetylation; Glycoprotein; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:B1AZA5"
FT CHAIN 2..868
FT /note="Transmembrane protein 245"
FT /id="PRO_0000417168"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 626..646
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 650..670
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 734..754
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 755..775
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 779..799
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 818..838
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:B1AZA5"
FT MOD_RES 12
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:B1AZA5"
FT MOD_RES 16
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:B1AZA5"
FT MOD_RES 39
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9H330"
FT MOD_RES 327
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H330"
FT MOD_RES 330
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:D3ZXD8"
FT MOD_RES 332
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9H330"
FT CARBOHYD 213
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 500
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 551
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 575
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 868 AA; 96123 MW; BD15222A099287C2 CRC64;
MADDGGPEEA LSPRGSPSRV PRVQRPVGAA SGGGGCGETP RTAALALRFD KPIKQAFYNT
GAVLFVCLCC GAAVLVYFIL EAFLRPLLWA VLCGTFLHPF KSSLTRLGRH WLQRLHRAHT
PIVLAALLLP ICFADYGVEA LGEQALRRRR LLLLLGAGGP LLYGLYSLGS YLGVQVLLAH
AGALICCGLD YFNSLWIWTL VVGYVLAVSF KWNASTERYL RAMSIPVWII LLFHLASLAG
AWRIPVFLVI VFLMSVGTLY EKQNGKESSG AELPGQVISM AASTLATLAI SITGYESSTE
DHTSTQPAET ETMDRGEPPP TLSSSSSPTS PSPPPGRQRS EAGTFLRKKK TSDVYFVSLL
WAIVGVQIWS NLWIVQLLPV PIAVWVLKKL VIHFGVVNFL EKRCSVWWQA TEHFLRERQQ
ALAPWPIIGL GKFLLKVDSK LWHWLNKKMI IWLEKMLDKI ISIFIIFLLV IGTLLLALLL
TAKVHQESVH MIEVTSNLIN ETLANHPEWA NWLPEAQVVQ RALNSAANNV YQYGREWITH
KLHKILGDKV NNTAVIEKQV LELWDRLYHS WFVKNVSHSG RHRGHKLHIS RQNSWLGDIL
DWQDIASFVH ENIETFLSIL ESLWVVMSRN VSLLFSTITT LLTILFYSGT ALLNFVLSLI
IFLTTLFYLL SSSDEYYKPV KWVISLTPLS QPGPSSNIIG QSVEEAIRHS RGVFDASLKM
AGFYGLYTWL THTIFGINIV FIPSALAAIL GAVPFLGTYW AAVPAVLDLW LTQGLGCKAI
LLLVFHLLPT YFVDTAIYSD ISGGGHPYLT GLAVAGGAYY LGLEGAIIGP ILLCILVVAS
NIYSAMLVSP TNSVPTPNQT PWPAQAQR
