ID   TM247_HUMAN             Reviewed;         219 AA.
AC   A6NEH6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 2.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Transmembrane protein 247;
GN   Name=TMEM247;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC018682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS56117.1; -.
DR   RefSeq; NP_001138523.1; NM_001145051.2.
DR   AlphaFoldDB; A6NEH6; -.
DR   SMR; A6NEH6; -.
DR   STRING; 9606.ENSP00000388684; -.
DR   iPTMnet; A6NEH6; -.
DR   PhosphoSitePlus; A6NEH6; -.
DR   BioMuta; TMEM247; -.
DR   MassIVE; A6NEH6; -.
DR   PaxDb; A6NEH6; -.
DR   PeptideAtlas; A6NEH6; -.
DR   PRIDE; A6NEH6; -.
DR   ProteomicsDB; 983; -.
DR   DNASU; 388946; -.
DR   Ensembl; ENST00000434431.2; ENSP00000388684.1; ENSG00000284701.1.
DR   GeneID; 388946; -.
DR   KEGG; hsa:388946; -.
DR   UCSC; uc061ivl.1; human.
DR   CTD; 388946; -.
DR   GeneCards; TMEM247; -.
DR   HGNC; HGNC:42967; TMEM247.
DR   HPA; ENSG00000284701; Tissue enriched (testis).
DR   neXtProt; NX_A6NEH6; -.
DR   VEuPathDB; HostDB:ENSG00000284701; -.
DR   eggNOG; ENOG502SRZ8; Eukaryota.
DR   GeneTree; ENSGT00390000002879; -.
DR   HOGENOM; CLU_112717_0_0_1; -.
DR   InParanoid; A6NEH6; -.
DR   OMA; DPMSEGK; -.
DR   OrthoDB; 1081739at2759; -.
DR   PhylomeDB; A6NEH6; -.
DR   TreeFam; TF337834; -.
DR   PathwayCommons; A6NEH6; -.
DR   SignaLink; A6NEH6; -.
DR   BioGRID-ORCS; 388946; 6 hits in 987 CRISPR screens.
DR   GenomeRNAi; 388946; -.
DR   Pharos; A6NEH6; Tdark.
DR   PRO; PR:A6NEH6; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; A6NEH6; protein.
DR   Bgee; ENSG00000284701; Expressed in right testis and 18 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR029200; TMEM247.
DR   PANTHER; PTHR36691; PTHR36691; 2.
DR   Pfam; PF15444; TMEM247; 2.
PE   4: Predicted;
KW   Coiled coil; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..219
FT                   /note="Transmembrane protein 247"
FT                   /id="PRO_0000328813"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          121..156
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        29..52
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   219 AA;  25168 MW;  83A376D61158E80E CRC64;
     MAAEDREMME ARGAGESCPT FPKMVPGDSK SEGKPRAYLE AESQKPDSSY DYLEEMEACE
     DGGCQGPLKS LSPKSCRATK GQAGDGPKPA ELPPTPGTER NPEMELEKVR MEFELTRLKY
     LHEKNQRQRQ HEVVMEQLQR ERQHEVVMEQ LQQEAAPRLF SGGLQNFLLP QNQFAMFLYC
     FIFIHIIYVT KEMVFFLFAK HYLFCIAAIL LCLIKTFWS