TM247_MOUSE
ID TM247_MOUSE Reviewed; 211 AA.
AC Q497K7; Q8BVQ7; Q9CU05;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Transmembrane protein 247;
GN Name=Tmem247;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI00487.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK018916; BAB31481.1; -; mRNA.
DR EMBL; AK076910; BAC36525.1; -; mRNA.
DR EMBL; BC100486; AAI00487.1; ALT_INIT; mRNA.
DR CCDS; CCDS79579.1; -.
DR RefSeq; NP_001264909.1; NM_001277980.1.
DR RefSeq; NP_084380.1; NM_030104.1.
DR AlphaFoldDB; Q497K7; -.
DR SMR; Q497K7; -.
DR STRING; 10090.ENSMUSP00000039338; -.
DR iPTMnet; Q497K7; -.
DR PhosphoSitePlus; Q497K7; -.
DR PaxDb; Q497K7; -.
DR PRIDE; Q497K7; -.
DR ProteomicsDB; 262826; -.
DR Ensembl; ENSMUST00000042172; ENSMUSP00000039338; ENSMUSG00000037689.
DR GeneID; 78469; -.
DR KEGG; mmu:78469; -.
DR UCSC; uc008duk.2; mouse.
DR CTD; 388946; -.
DR MGI; MGI:1925719; Tmem247.
DR VEuPathDB; HostDB:ENSMUSG00000037689; -.
DR eggNOG; ENOG502SRZ8; Eukaryota.
DR GeneTree; ENSGT00390000002879; -.
DR HOGENOM; CLU_112717_0_0_1; -.
DR InParanoid; Q497K7; -.
DR OMA; DPMSEGK; -.
DR OrthoDB; 1081739at2759; -.
DR PhylomeDB; Q497K7; -.
DR TreeFam; TF337834; -.
DR BioGRID-ORCS; 78469; 1 hit in 65 CRISPR screens.
DR PRO; PR:Q497K7; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q497K7; protein.
DR Bgee; ENSMUSG00000037689; Expressed in seminiferous tubule of testis and 7 other tissues.
DR ExpressionAtlas; Q497K7; baseline and differential.
DR Genevisible; Q497K7; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029200; TMEM247.
DR PANTHER; PTHR36691; PTHR36691; 1.
DR Pfam; PF15444; TMEM247; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..211
FT /note="Transmembrane protein 247"
FT /id="PRO_0000328814"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 119..148
FT /evidence="ECO:0000255"
FT CONFLICT 178..179
FT /note="II -> MM (in Ref. 1; BAB31481)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 211 AA; 23971 MW; 147D4E95953C8C13 CRC64;
MAMEDREVME ARGAGESCPT LSKVAPVDSM PEGKPKASLD AEVPKLELPT LEENGICEDR
DCPGPPRSLP PKSGPNAKGQ AGDGPGLESV ELPLPLETEH RNAMELEKVR MEFELTLLKY
LHQENERQRQ HEEVMEQLQQ QQQQQQALPH QFSGSLQDLL LPQNQFAMFF YCFIFIHIIY
VAKETVFFLF SKHYLFCLAA ILLCLIKTLW S
