ID   TM248_BOVIN             Reviewed;         314 AA.
AC   Q2YDM0;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Transmembrane protein 248;
GN   Name=TMEM248;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM248 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC110157; AAI10158.1; -; mRNA.
DR   RefSeq; NP_001039546.1; NM_001046081.2.
DR   RefSeq; XP_005224937.1; XM_005224880.2.
DR   AlphaFoldDB; Q2YDM0; -.
DR   PaxDb; Q2YDM0; -.
DR   PRIDE; Q2YDM0; -.
DR   Ensembl; ENSBTAT00000085793; ENSBTAP00000057794; ENSBTAG00000002935.
DR   GeneID; 511252; -.
DR   KEGG; bta:511252; -.
DR   CTD; 55069; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002935; -.
DR   VGNC; VGNC:36057; TMEM248.
DR   eggNOG; ENOG502R6D8; Eukaryota.
DR   GeneTree; ENSGT00940000153883; -.
DR   HOGENOM; CLU_080742_0_0_1; -.
DR   InParanoid; Q2YDM0; -.
DR   OMA; DYNPLWC; -.
DR   TreeFam; TF331542; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000002935; Expressed in corpus epididymis and 102 other tissues.
DR   ExpressionAtlas; Q2YDM0; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR039493; TMEM248/TMEM219.
DR   InterPro; IPR039587; TMEM248/TMEM219_dom.
DR   PANTHER; PTHR16002; PTHR16002; 1.
DR   Pfam; PF14940; TMEM219; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..314
FT                   /note="Transmembrane protein 248"
FT                   /id="PRO_0000295125"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          79..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        79..106
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   314 AA;  35068 MW;  FFBB0D3A065B3E65 CRC64;
     MFNINPLENL KLYISSRPPL VVFMISVSAM AIAFLTLGYF FKIKEIKSPE MAEDWNTFLL
     RFNDLDLCVS ENETLKHLTN DTAAPESTVT SGQARTSTQS PQPLEDAGPV NISVAITLTL
     DPLKPFGGYS RNVTHLYSTI LGHQIGLSGR EAQEEINITF TLPTSWSSDD CALHGHCEQV
     VFTACMTLTA HPGVFPVTVQ PPHCVPDTYS NATLWYKIFT TARDANTKYA QDYNPFWCYK
     GAIGKVYHAL NPKLTVIVPD DDRSLINLHL MHTSYFLFVM VITMFCYAVI KGRPSKLRQS
     NPEFCPEKVA LADA