ID   TM248_DANRE             Reviewed;         315 AA.
AC   Q5BKX0;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Transmembrane protein 248;
GN   Name=tmem248; ORFNames=zgc:103561;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM248 family. {ECO:0000305}.
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DR   EMBL; BC090900; AAH90900.1; -; mRNA.
DR   RefSeq; NP_001013548.1; NM_001013530.1.
DR   AlphaFoldDB; Q5BKX0; -.
DR   STRING; 7955.ENSDARP00000027014; -.
DR   PaxDb; Q5BKX0; -.
DR   GeneID; 541403; -.
DR   KEGG; dre:541403; -.
DR   CTD; 55069; -.
DR   ZFIN; ZDB-GENE-050320-103; tmem248.
DR   eggNOG; ENOG502R6D8; Eukaryota.
DR   InParanoid; Q5BKX0; -.
DR   OrthoDB; 1623112at2759; -.
DR   PhylomeDB; Q5BKX0; -.
DR   PRO; PR:Q5BKX0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR039493; TMEM248/TMEM219.
DR   InterPro; IPR039587; TMEM248/TMEM219_dom.
DR   PANTHER; PTHR16002; PTHR16002; 1.
DR   Pfam; PF14940; TMEM219; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..315
FT                   /note="Transmembrane protein 248"
FT                   /id="PRO_0000295129"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          81..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..105
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   315 AA;  35447 MW;  6417391845ABDFAF CRC64;
     MVLLLNPLEN LKTYISNRPP LVIFMVSVSA VAIAFLTIGY FFKIKEIKSP EMTEDWNTFL
     LRFNEIDFCI SENETLKHGL NESITPESTV TSSQTRSSTQ SPPLLEDPGP INISVAITLT
     LDPLRPFGGY SRNITHLYAS VLGQQVGLAG REAHEEMNIT FTLPVAWNSD ECVLHGRCEQ
     MVFSTCMTVT AASNVFPVTM QPPHCVPETY SNATSWYKIF TTARDSDTKY TQEYNPFWCY
     KGAIGKVYHT LNPKLTVIVP DDDRSLINLH LMHTSYFLFV MVITMFCYAV IKGRPGKVRQ
     NNPDFCQEKV ALSAG