TM248_MOUSE
ID TM248_MOUSE Reviewed; 314 AA.
AC Q3TBN1; Q8CIB2; Q9DD07;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Transmembrane protein 248;
GN Name=Tmem248;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Dendritic cell, Heart, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM248 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB21996.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK002297; BAB21996.1; ALT_FRAME; mRNA.
DR EMBL; AK142176; BAE24962.1; -; mRNA.
DR EMBL; AK171152; BAE42278.1; -; mRNA.
DR EMBL; BC033455; AAH33455.1; -; mRNA.
DR CCDS; CCDS39295.1; -.
DR RefSeq; NP_001074863.1; NM_001081394.1.
DR RefSeq; NP_082130.1; NM_027854.1.
DR RefSeq; XP_011239209.1; XM_011240907.2.
DR AlphaFoldDB; Q3TBN1; -.
DR STRING; 10090.ENSMUSP00000106929; -.
DR iPTMnet; Q3TBN1; -.
DR PhosphoSitePlus; Q3TBN1; -.
DR EPD; Q3TBN1; -.
DR PaxDb; Q3TBN1; -.
DR PeptideAtlas; Q3TBN1; -.
DR PRIDE; Q3TBN1; -.
DR ProteomicsDB; 262827; -.
DR Antibodypedia; 3083; 64 antibodies from 16 providers.
DR Ensembl; ENSMUST00000065329; ENSMUSP00000067501; ENSMUSG00000053094.
DR Ensembl; ENSMUST00000111298; ENSMUSP00000106929; ENSMUSG00000053094.
DR GeneID; 71667; -.
DR KEGG; mmu:71667; -.
DR UCSC; uc008zuh.1; mouse.
DR CTD; 55069; -.
DR MGI; MGI:1918917; Tmem248.
DR VEuPathDB; HostDB:ENSMUSG00000053094; -.
DR eggNOG; ENOG502R6D8; Eukaryota.
DR GeneTree; ENSGT00940000153883; -.
DR HOGENOM; CLU_080742_0_0_1; -.
DR InParanoid; Q3TBN1; -.
DR OMA; DYNPLWC; -.
DR OrthoDB; 1623112at2759; -.
DR PhylomeDB; Q3TBN1; -.
DR TreeFam; TF331542; -.
DR BioGRID-ORCS; 71667; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Tmem248; mouse.
DR PRO; PR:Q3TBN1; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q3TBN1; protein.
DR Bgee; ENSMUSG00000053094; Expressed in lacrimal gland and 223 other tissues.
DR ExpressionAtlas; Q3TBN1; baseline and differential.
DR Genevisible; Q3TBN1; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR039493; TMEM248/TMEM219.
DR InterPro; IPR039587; TMEM248/TMEM219_dom.
DR PANTHER; PTHR16002; PTHR16002; 1.
DR Pfam; PF14940; TMEM219; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Transmembrane protein 248"
FT /id="PRO_0000295127"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 78..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 63
FT /note="N -> D (in Ref. 2; AAH33455)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 314 AA; 35041 MW; FC21A7434BA1C2EF CRC64;
MFSINPLENL KLYISSRPPL VVFMISVSAM AIAFLTLGYF FKIKEIKSPE MAEDWNTFLL
RFNDLDLCVS ENETLKHLSN DTTTPESTMT VGQARSSTQP PQSLEESGPI NISVAITLTL
DPLKPFGGYS RNVTHLYSTI LGHQIGLSGR EAHEEINITF TLPAAWNADD CALHGHCEQA
VFTACMTLTA APGVFPVTVQ PPHCIPDTYS NATLWYKIFT TARDANTKYA QDYNPFWCYK
GAIGKVYHAL NPKLTVVVPD DDRSLINLHL MHTSYFLFVM VITMFCYAVI KGRPSKLRQS
NPEFCPEKVA LADA
