ID   TM248_RAT               Reviewed;         314 AA.
AC   Q6AY76;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Transmembrane protein 248;
GN   Name=Tmem248;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM248 family. {ECO:0000305}.
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DR   EMBL; BC079161; AAH79161.1; -; mRNA.
DR   EMBL; BC090318; AAH90318.1; -; mRNA.
DR   RefSeq; NP_001004204.1; NM_001004204.2.
DR   RefSeq; XP_006249292.1; XM_006249230.3.
DR   RefSeq; XP_006249293.1; XM_006249231.3.
DR   AlphaFoldDB; Q6AY76; -.
DR   STRING; 10116.ENSRNOP00000055516; -.
DR   iPTMnet; Q6AY76; -.
DR   PhosphoSitePlus; Q6AY76; -.
DR   PaxDb; Q6AY76; -.
DR   Ensembl; ENSRNOT00000058725; ENSRNOP00000055516; ENSRNOG00000000893.
DR   GeneID; 288616; -.
DR   KEGG; rno:288616; -.
DR   CTD; 55069; -.
DR   RGD; 1303319; Tmem248.
DR   eggNOG; ENOG502R6D8; Eukaryota.
DR   GeneTree; ENSGT00940000153883; -.
DR   HOGENOM; CLU_080742_0_0_1; -.
DR   InParanoid; Q6AY76; -.
DR   OMA; DYNPLWC; -.
DR   OrthoDB; 1623112at2759; -.
DR   PhylomeDB; Q6AY76; -.
DR   TreeFam; TF331542; -.
DR   PRO; PR:Q6AY76; -.
DR   Proteomes; UP000002494; Chromosome 12.
DR   Bgee; ENSRNOG00000000893; Expressed in pancreas and 20 other tissues.
DR   Genevisible; Q6AY76; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR039493; TMEM248/TMEM219.
DR   InterPro; IPR039587; TMEM248/TMEM219_dom.
DR   PANTHER; PTHR16002; PTHR16002; 1.
DR   Pfam; PF14940; TMEM219; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..314
FT                   /note="Transmembrane protein 248"
FT                   /id="PRO_0000295128"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          78..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   314 AA;  35113 MW;  B3AAC303DA666314 CRC64;
     MFSINPLENL KLYISSRPPL VVFMISVSAM AIAFLTLGYF FKIKEIKSPE MAEDWNTFLL
     RFNDLDLCVS ENETLKHLSN DTTTPESTMT IGQTRSSTQP PQSLEESGPI NISVAITLTL
     DPLKPFGGYS RNVTHLYSTI LGHQIGLSGR EAHEEINITF TLPAAWNADD CALHGHCEQV
     VFTACMTLTA APGVFPVTVQ PPHCVPDTYS NATLWYKIFT TARDANTKYA QDYNPFWCYK
     GAIGKVYHAL NPKLTVIVPD DDRSLINLHL MHTSYFLFVM VITMFCYAVI KGRPSKLRQS
     NPEFCPEKVA LADA