ID   TM248_XENLA             Reviewed;         315 AA.
AC   Q2TAV2;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Transmembrane protein 248;
GN   Name=tmem248;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM248 family. {ECO:0000305}.
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DR   EMBL; BC110716; AAI10717.1; -; mRNA.
DR   AlphaFoldDB; Q2TAV2; -.
DR   SMR; Q2TAV2; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR039493; TMEM248/TMEM219.
DR   InterPro; IPR039587; TMEM248/TMEM219_dom.
DR   PANTHER; PTHR16002; PTHR16002; 1.
DR   Pfam; PF14940; TMEM219; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..315
FT                   /note="Transmembrane protein 248"
FT                   /id="PRO_0000295130"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          82..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   315 AA;  35277 MW;  81BC0951EC538F48 CRC64;
     MILNLHPLEN LKSYISSRPP LVIFMVSVSG MAIAFLTLGY FFKMKEIKSP GMTEDWNIFL
     LRFNNLDLCV SENETLKHFL NETTPPESTV TSGQARSSTQ TPQALEDSGP INISVAITLT
     LDPLKPFGGY SRNITHLSST IFGHQIGLSG RDSHEEMNIT FTLPAAWNSD DCIVHGHCEQ
     VVFTTCMTVT AVTNVFPVTV QPPHCIPETY SNASLWYKIY TTARDSGTKN AQDYNPFWCY
     KGAIGKVYHA LNPKLTVIVP EDDRSLINLH LMDTSYFLFV MVITMFCYAV IRGRPSKLRQ
     SKSEFLPEKV ALSDA