ID   TM248_XENTR             Reviewed;         315 AA.
AC   Q68FB2;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Transmembrane protein 248;
GN   Name=tmem248;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM248 family. {ECO:0000305}.
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DR   EMBL; BC079930; AAH79930.1; -; mRNA.
DR   RefSeq; NP_001007494.1; NM_001007493.1.
DR   AlphaFoldDB; Q68FB2; -.
DR   SMR; Q68FB2; -.
DR   PaxDb; Q68FB2; -.
DR   DNASU; 493220; -.
DR   GeneID; 493220; -.
DR   KEGG; xtr:493220; -.
DR   CTD; 55069; -.
DR   Xenbase; XB-GENE-5803741; tmem248.
DR   eggNOG; ENOG502R6D8; Eukaryota.
DR   HOGENOM; CLU_080742_0_0_1; -.
DR   InParanoid; Q68FB2; -.
DR   OMA; XREAHEE; -.
DR   OrthoDB; 1623112at2759; -.
DR   PhylomeDB; Q68FB2; -.
DR   TreeFam; TF331542; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR039493; TMEM248/TMEM219.
DR   InterPro; IPR039587; TMEM248/TMEM219_dom.
DR   PANTHER; PTHR16002; PTHR16002; 1.
DR   Pfam; PF14940; TMEM219; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..315
FT                   /note="Transmembrane protein 248"
FT                   /id="PRO_0000295131"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          82..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   315 AA;  35245 MW;  C595F65A12D4DBAC CRC64;
     MILILHPLEN LKSYISSRPP LVIFMVSVSG MAIAFLTLGY FFKMKEIKSP EMTEDWNTFL
     LRFNNLDLCV SENETLKHFL NETTPPESTV TSGQARSSTQ TPQALEDSGP INISVAITLT
     LDPLKPFGGY SRNITHLSST IFGHQIGLSG RDSHEEMNIT FTLPAAWNSD DCIVHGHCEQ
     VVFTTCMTVT AASSVFPVTV QPPHCIPETY SNASLWYKIF TTARDSGTKY AQDYNPFWCY
     KGAVGKVYHA LNPKLTVIVP EDDRSLINLH LMDTSYFLFV MVITMFCYAV IRGRPSKLRQ
     SNSEFSPEKV ALSDA