TM251_MOUSE
ID TM251_MOUSE Reviewed; 163 AA.
AC Q8BH26;
DT 02-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Transmembrane protein 251;
GN Name=Tmem251;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye, and Olfactory bulb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Golgi apparatus {ECO:0000250|UniProtKB:Q8N6I4}.
CC -!- SIMILARITY: Belongs to the TMEM251 family. {ECO:0000305}.
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DR EMBL; AK032513; BAC27904.1; -; mRNA.
DR EMBL; AK052027; BAC34834.1; -; mRNA.
DR EMBL; BC096606; AAH96606.1; -; mRNA.
DR CCDS; CCDS49146.1; -.
DR RefSeq; NP_001311444.1; NM_001324515.1.
DR RefSeq; NP_796114.1; NM_177140.3.
DR AlphaFoldDB; Q8BH26; -.
DR STRING; 10090.ENSMUSP00000054611; -.
DR SwissPalm; Q8BH26; -.
DR PaxDb; Q8BH26; -.
DR PRIDE; Q8BH26; -.
DR ProteomicsDB; 259107; -.
DR Antibodypedia; 64066; 5 antibodies from 5 providers.
DR DNASU; 320351; -.
DR Ensembl; ENSMUST00000057416; ENSMUSP00000054611; ENSMUSG00000046675.
DR GeneID; 320351; -.
DR KEGG; mmu:320351; -.
DR UCSC; uc007oul.1; mouse.
DR CTD; 26175; -.
DR MGI; MGI:2443862; Tmem251.
DR VEuPathDB; HostDB:ENSMUSG00000046675; -.
DR eggNOG; ENOG502RY2J; Eukaryota.
DR GeneTree; ENSGT00390000007473; -.
DR HOGENOM; CLU_133007_0_0_1; -.
DR InParanoid; Q8BH26; -.
DR OMA; AYYIFEV; -.
DR OrthoDB; 1528152at2759; -.
DR PhylomeDB; Q8BH26; -.
DR TreeFam; TF332722; -.
DR BioGRID-ORCS; 320351; 6 hits in 71 CRISPR screens.
DR ChiTaRS; Tmem251; mouse.
DR PRO; PR:Q8BH26; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8BH26; protein.
DR Bgee; ENSMUSG00000046675; Expressed in peripheral nervous system and 74 other tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028024; TMEM251.
DR PANTHER; PTHR31925; PTHR31925; 1.
DR Pfam; PF15190; TMEM251; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..163
FT /note="Transmembrane protein 251"
FT /id="PRO_0000089917"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 163 AA; 18720 MW; 55AF92B104E90506 CRC64;
MPKAPDCSEL SDSCSLAGGT GRFSGPLHRA WRMMNFRQRM GWIGVGLYLL ASAAAFYYVF
EINETYNRLA LEHILQHPEE PREGTTWTHS LKARLLSLPF WLWTIIFLIP YLQMFLFLYS
CTRADPKTVG YCIIPICLAV ICNRHQAFVK ASNQISRLQL IDT
