ID   TM251_XENTR             Reviewed;         162 AA.
AC   Q5HZT8; A0JPC2; Q28GR7;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 2.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Transmembrane protein 251;
GN   Name=tmem251; ORFNames=TEgg078g21.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=N6; TISSUE=Lung;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}. Golgi apparatus {ECO:0000250|UniProtKB:Q8N6I4}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5HZT8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5HZT8-2; Sequence=VSP_036174;
CC   -!- SIMILARITY: Belongs to the TMEM251 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH88890.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAI27356.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CR761254; CAJ82061.1; -; mRNA.
DR   EMBL; BC088890; AAH88890.1; ALT_INIT; mRNA.
DR   EMBL; BC127355; AAI27356.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001032343.1; NM_001037266.1.
DR   RefSeq; XP_012823780.1; XM_012968326.2. [Q5HZT8-1]
DR   AlphaFoldDB; Q5HZT8; -.
DR   SMR; Q5HZT8; -.
DR   STRING; 8364.ENSXETP00000056707; -.
DR   PaxDb; Q5HZT8; -.
DR   DNASU; 497000; -.
DR   Ensembl; ENSXETT00000056707; ENSXETP00000056707; ENSXETG00000027035.
DR   GeneID; 497000; -.
DR   KEGG; xtr:497000; -.
DR   CTD; 26175; -.
DR   Xenbase; XB-GENE-971513; tmem251.
DR   eggNOG; ENOG502RY2J; Eukaryota.
DR   HOGENOM; CLU_133007_0_0_1; -.
DR   InParanoid; Q5HZT8; -.
DR   OrthoDB; 1528152at2759; -.
DR   PhylomeDB; Q5HZT8; -.
DR   TreeFam; TF332722; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000027035; Expressed in ovary and 15 other tissues.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR028024; TMEM251.
DR   PANTHER; PTHR31925; PTHR31925; 1.
DR   Pfam; PF15190; TMEM251; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Golgi apparatus; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..162
FT                   /note="Transmembrane protein 251"
FT                   /id="PRO_0000359888"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..31
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_036174"
SQ   SEQUENCE   162 AA;  18945 MW;  12FD421182C04B2E CRC64;
     MWRVEFVACL RPSCQFCTAM CSILSAGRAW RMMNFRQRMG WIGVSLYLFV SAAAFYYVFE
     INETYNRLAL EHVQLKPQEP HRGTTWTHSL KARLLSLPFW LWAALFLIPY FQVFLFLYSC
     TRADPKTVGY CIIPICLAII CNRHQSFVKA SNQISRLQLI DT