TM252_MOUSE
ID TM252_MOUSE Reviewed; 183 AA.
AC Q8C353; Q3UP68;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Transmembrane protein 252;
GN Name=Tmem252;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Lung, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK086895; BAC39758.1; -; mRNA.
DR EMBL; AK143762; BAE25529.1; -; mRNA.
DR EMBL; BC087877; AAH87877.1; -; mRNA.
DR CCDS; CCDS29713.1; -.
DR RefSeq; NP_898983.1; NM_183160.3.
DR AlphaFoldDB; Q8C353; -.
DR STRING; 10090.ENSMUSP00000060863; -.
DR iPTMnet; Q8C353; -.
DR PhosphoSitePlus; Q8C353; -.
DR MaxQB; Q8C353; -.
DR PaxDb; Q8C353; -.
DR PRIDE; Q8C353; -.
DR ProteomicsDB; 259557; -.
DR Antibodypedia; 51987; 39 antibodies from 6 providers.
DR DNASU; 226040; -.
DR Ensembl; ENSMUST00000057243; ENSMUSP00000060863; ENSMUSG00000048572.
DR GeneID; 226040; -.
DR KEGG; mmu:226040; -.
DR UCSC; uc008har.1; mouse.
DR CTD; 169693; -.
DR MGI; MGI:3583948; Tmem252.
DR VEuPathDB; HostDB:ENSMUSG00000048572; -.
DR eggNOG; ENOG502S6KQ; Eukaryota.
DR GeneTree; ENSGT00390000005250; -.
DR HOGENOM; CLU_117690_0_0_1; -.
DR InParanoid; Q8C353; -.
DR OMA; LYTEMGL; -.
DR OrthoDB; 1607376at2759; -.
DR PhylomeDB; Q8C353; -.
DR TreeFam; TF337811; -.
DR BioGRID-ORCS; 226040; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q8C353; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q8C353; protein.
DR Bgee; ENSMUSG00000048572; Expressed in proximal tubule and 121 other tissues.
DR Genevisible; Q8C353; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031363; TMEM252.
DR PANTHER; PTHR35682; PTHR35682; 1.
DR Pfam; PF15664; TMEM252; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..183
FT /note="Transmembrane protein 252"
FT /id="PRO_0000089708"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 183 AA; 20376 MW; 350C1802D06094DB CRC64;
MQNRTGLILC ALSLLTGFLM ICLGGFFISN SIFHSQRNLV VAYVLLPMGF VILLSGIFWG
TYRQANENKE MFNHVLRQHL AFQDLPLATV DRPDFYPPAY EESLDVEKQA CPAGRELLGF
PPPLYTETNL EFEHLEDPQP EAPPPYQEII ADAGAPAKAQ DAEEPSRVLK AGTALQLTEL
TGR
