ID   TM253_BOVIN             Reviewed;         165 AA.
AC   Q0II74;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Transmembrane protein 253;
GN   Name=TMEM253;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BC122773; AAI22774.1; -; mRNA.
DR   RefSeq; NP_001069196.1; NM_001075728.2.
DR   AlphaFoldDB; Q0II74; -.
DR   PaxDb; Q0II74; -.
DR   PRIDE; Q0II74; -.
DR   Ensembl; ENSBTAT00000055545; ENSBTAP00000051437; ENSBTAG00000032908.
DR   GeneID; 515865; -.
DR   KEGG; bta:515865; -.
DR   CTD; 643382; -.
DR   VEuPathDB; HostDB:ENSBTAG00000032908; -.
DR   VGNC; VGNC:36062; TMEM253.
DR   eggNOG; ENOG502S0TM; Eukaryota.
DR   GeneTree; ENSGT00400000023212; -.
DR   HOGENOM; CLU_1405518_0_0_1; -.
DR   InParanoid; Q0II74; -.
DR   OMA; VRIHRWF; -.
DR   TreeFam; TF354003; -.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000032908; Expressed in rumen papilla and 52 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR038874; TMEM253.
DR   PANTHER; PTHR37359; PTHR37359; 2.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..165
FT                   /note="Transmembrane protein 253"
FT                   /id="PRO_0000343721"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          145..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   165 AA;  18153 MW;  77351F419F258122 CRC64;
     MEDRAGQQER PSLRLEKLQH WARHRQSGRL LVLAVSQLWL AVAVVPFAVS VACLNSACHM
     TTALPLGPGI LGLLTGIVTL ELRRAPRLWK LAGLLVLELS AEAFTLGGVL VSAYSLFLLS
     QRKPRCCRSQ SLRYQELQEG LSELEEVPEL ETGPTVASTA KRTNQ