ID   TM253_HUMAN             Reviewed;         217 AA.
AC   P0C7T8;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Transmembrane protein 253;
GN   Name=TMEM253; Synonyms=C14orf176, C14orf95;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA   Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA   Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA   Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA   Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA   Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA   Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA   Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA   Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA   Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA   Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA   Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA   Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA   Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AL161668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS53884.1; -.
DR   RefSeq; NP_001140155.1; NM_001146683.1.
DR   RefSeq; XP_006720296.1; XM_006720233.3.
DR   RefSeq; XP_011535380.1; XM_011537078.2.
DR   RefSeq; XP_011535381.1; XM_011537079.1.
DR   AlphaFoldDB; P0C7T8; -.
DR   BioGRID; 568735; 2.
DR   IntAct; P0C7T8; 2.
DR   STRING; 9606.ENSP00000453962; -.
DR   PhosphoSitePlus; P0C7T8; -.
DR   BioMuta; TMEM253; -.
DR   DMDM; 206557836; -.
DR   MassIVE; P0C7T8; -.
DR   PaxDb; P0C7T8; -.
DR   PeptideAtlas; P0C7T8; -.
DR   PRIDE; P0C7T8; -.
DR   ProteomicsDB; 52367; -.
DR   Antibodypedia; 62200; 8 antibodies from 4 providers.
DR   DNASU; 643382; -.
DR   Ensembl; ENST00000418511.6; ENSP00000453962.1; ENSG00000232070.9.
DR   Ensembl; ENST00000556585.2; ENSP00000451229.2; ENSG00000232070.9.
DR   GeneID; 643382; -.
DR   KEGG; hsa:643382; -.
DR   MANE-Select; ENST00000556585.3; ENSP00000451229.2; NM_001395467.1; NP_001382396.1.
DR   UCSC; uc010tlo.2; human.
DR   CTD; 643382; -.
DR   GeneCards; TMEM253; -.
DR   HGNC; HGNC:32545; TMEM253.
DR   HPA; ENSG00000232070; Tissue enriched (intestine).
DR   neXtProt; NX_P0C7T8; -.
DR   OpenTargets; ENSG00000232070; -.
DR   PharmGKB; PA143485392; -.
DR   VEuPathDB; HostDB:ENSG00000232070; -.
DR   eggNOG; ENOG502S0TM; Eukaryota.
DR   GeneTree; ENSGT00400000023212; -.
DR   HOGENOM; CLU_1405518_0_0_1; -.
DR   InParanoid; P0C7T8; -.
DR   OMA; VRIHRWF; -.
DR   OrthoDB; 1344978at2759; -.
DR   PhylomeDB; P0C7T8; -.
DR   TreeFam; TF354003; -.
DR   PathwayCommons; P0C7T8; -.
DR   SignaLink; P0C7T8; -.
DR   BioGRID-ORCS; 643382; 10 hits in 1065 CRISPR screens.
DR   GenomeRNAi; 643382; -.
DR   Pharos; P0C7T8; Tdark.
DR   PRO; PR:P0C7T8; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   RNAct; P0C7T8; protein.
DR   Bgee; ENSG00000232070; Expressed in duodenum and 94 other tissues.
DR   ExpressionAtlas; P0C7T8; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR038874; TMEM253.
DR   PANTHER; PTHR37359; PTHR37359; 1.
PE   4: Predicted;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..217
FT                   /note="Transmembrane protein 253"
FT                   /id="PRO_0000343722"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          187..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   217 AA;  23522 MW;  C6964904189C64F2 CRC64;
     MEDRAGEQEQ ERHSLRLEKL QHWARHRQSG HLLVLAVSQL WLAVVVVPLA VSVACLNSDC
     HMATALPLGP GASGLLTGTV TLELRRAPRL WKVRAMMIFN TFNLILGFIV VVVEVMKTAL
     GPAPTASSQH AGLLVLELSA EAFTLGGVLV SVHALFLLSQ RKPGCCRSQS LHYQELQEGF
     SELEEVPGLE NGPTVASTGA NERVGQREQT RAALLPP