TM253_MOUSE
ID TM253_MOUSE Reviewed; 204 AA.
AC Q3UNB8;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Transmembrane protein 253;
GN Name=Tmem253;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Intestinal mucosa;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK144313; BAE25829.1; -; mRNA.
DR EMBL; BC147689; AAI47690.1; -; mRNA.
DR CCDS; CCDS27049.1; -.
DR RefSeq; NP_001028977.1; NM_001033805.3.
DR RefSeq; XP_011243430.1; XM_011245128.2.
DR RefSeq; XP_017171594.1; XM_017316105.1.
DR AlphaFoldDB; Q3UNB8; -.
DR STRING; 10090.ENSMUSP00000098203; -.
DR PhosphoSitePlus; Q3UNB8; -.
DR PaxDb; Q3UNB8; -.
DR PeptideAtlas; Q3UNB8; -.
DR PRIDE; Q3UNB8; -.
DR Antibodypedia; 62200; 8 antibodies from 4 providers.
DR Ensembl; ENSMUST00000100638; ENSMUSP00000098203; ENSMUSG00000072571.
DR GeneID; 619301; -.
DR KEGG; mmu:619301; -.
DR UCSC; uc007tnz.1; mouse.
DR CTD; 643382; -.
DR MGI; MGI:3588246; Tmem253.
DR VEuPathDB; HostDB:ENSMUSG00000072571; -.
DR eggNOG; ENOG502S0TM; Eukaryota.
DR GeneTree; ENSGT00400000023212; -.
DR HOGENOM; CLU_1405518_0_0_1; -.
DR InParanoid; Q3UNB8; -.
DR OMA; VRIHRWF; -.
DR OrthoDB; 1344978at2759; -.
DR PhylomeDB; Q3UNB8; -.
DR TreeFam; TF354003; -.
DR BioGRID-ORCS; 619301; 3 hits in 70 CRISPR screens.
DR PRO; PR:Q3UNB8; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q3UNB8; protein.
DR Bgee; ENSMUSG00000072571; Expressed in jejunum and 60 other tissues.
DR ExpressionAtlas; Q3UNB8; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR038874; TMEM253.
DR PANTHER; PTHR37359; PTHR37359; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..204
FT /note="Transmembrane protein 253"
FT /id="PRO_0000343723"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 184..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 204 AA; 22415 MW; 4141ECEBD9EEB164 CRC64;
MDQNANQPRQ ERPSVRLEKL QHWARHKQSG RLLVLAVSQV WLAIAMVPFT ISVSCLTSAC
HLVTALPLWP GASGLLTGII TLELRRAPCI WKVRAMMISN TFNLILGFVA VVIEVMKTAL
GTASMDSSQS TGLLVLELSA EAFTLAGVLV STYALFLLSQ RKPGYFKRSR LQYRELQEGL
SEMEEVSGLE NGPVVASTGN RTDE
