ID   TM256_HUMAN             Reviewed;         113 AA.
AC   Q8N2U0;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Transmembrane protein 256;
DE   Flags: Precursor;
GN   Name=TMEM256; Synonyms=C17orf61;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM256 family. {ECO:0000305}.
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DR   EMBL; BC030270; AAH30270.1; -; mRNA.
DR   CCDS; CCDS11102.1; -.
DR   RefSeq; NP_689979.1; NM_152766.3.
DR   AlphaFoldDB; Q8N2U0; -.
DR   BioGRID; 129054; 16.
DR   IntAct; Q8N2U0; 13.
DR   STRING; 9606.ENSP00000301939; -.
DR   iPTMnet; Q8N2U0; -.
DR   PhosphoSitePlus; Q8N2U0; -.
DR   BioMuta; TMEM256; -.
DR   DMDM; 74728725; -.
DR   EPD; Q8N2U0; -.
DR   jPOST; Q8N2U0; -.
DR   MassIVE; Q8N2U0; -.
DR   MaxQB; Q8N2U0; -.
DR   PaxDb; Q8N2U0; -.
DR   PeptideAtlas; Q8N2U0; -.
DR   PRIDE; Q8N2U0; -.
DR   ProteomicsDB; 71735; -.
DR   TopDownProteomics; Q8N2U0; -.
DR   Antibodypedia; 76715; 30 antibodies from 9 providers.
DR   DNASU; 254863; -.
DR   Ensembl; ENST00000302422.4; ENSP00000301939.3; ENSG00000205544.4.
DR   Ensembl; ENST00000639136.2; ENSP00000491711.1; ENSG00000283771.2.
DR   GeneID; 254863; -.
DR   KEGG; hsa:254863; -.
DR   MANE-Select; ENST00000302422.4; ENSP00000301939.3; NM_152766.5; NP_689979.1.
DR   UCSC; uc002ggs.4; human.
DR   CTD; 254863; -.
DR   DisGeNET; 254863; -.
DR   GeneCards; TMEM256; -.
DR   HGNC; HGNC:28618; TMEM256.
DR   HPA; ENSG00000205544; Low tissue specificity.
DR   MIM; 617779; gene.
DR   neXtProt; NX_Q8N2U0; -.
DR   OpenTargets; ENSG00000205544; -.
DR   PharmGKB; PA142672244; -.
DR   VEuPathDB; HostDB:ENSG00000205544; -.
DR   eggNOG; KOG3472; Eukaryota.
DR   GeneTree; ENSGT00390000000334; -.
DR   HOGENOM; CLU_096548_1_2_1; -.
DR   InParanoid; Q8N2U0; -.
DR   OMA; YCLAGCH; -.
DR   OrthoDB; 1632823at2759; -.
DR   PhylomeDB; Q8N2U0; -.
DR   TreeFam; TF300271; -.
DR   PathwayCommons; Q8N2U0; -.
DR   SignaLink; Q8N2U0; -.
DR   BioGRID-ORCS; 254863; 9 hits in 1070 CRISPR screens.
DR   ChiTaRS; TMEM256; human.
DR   GenomeRNAi; 254863; -.
DR   Pharos; Q8N2U0; Tdark.
DR   PRO; PR:Q8N2U0; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q8N2U0; protein.
DR   Bgee; ENSG00000205544; Expressed in duodenum and 96 other tissues.
DR   ExpressionAtlas; Q8N2U0; baseline and differential.
DR   Genevisible; Q8N2U0; HS.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   InterPro; IPR006696; DUF423.
DR   PANTHER; PTHR43461; PTHR43461; 1.
DR   Pfam; PF04241; DUF423; 1.
PE   3: Inferred from homology;
KW   Acetylation; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..113
FT                   /note="Transmembrane protein 256"
FT                   /id="PRO_0000287170"
FT   TOPO_DOM        30..63
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        85..92
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         43
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5F285"
SQ   SEQUENCE   113 AA;  11742 MW;  3184A3767F5ABB0E CRC64;
     MAGPAAAFRR LGALSGAAAL GFASYGAHGA QFPDAYGKEL FDKANKHHFL HSLALLGVPH
     CRKPLWAGLL LASGTTLFCT SFYYQALSGD PSIQTLAPAG GTLLLLGWLA LAL