TM260_DICDI
ID TM260_DICDI Reviewed; 819 AA.
AC Q8MXQ3; Q553D9;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 2.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Transmembrane protein 260 homolog;
GN ORFNames=DDB_G0275853;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM260 family. {ECO:0000305}.
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DR EMBL; AAFI02000013; EAL69677.1; -; Genomic_DNA.
DR RefSeq; XP_643478.1; XM_638386.1.
DR AlphaFoldDB; Q8MXQ3; -.
DR PaxDb; Q8MXQ3; -.
DR EnsemblProtists; EAL69677; EAL69677; DDB_G0275853.
DR GeneID; 8620059; -.
DR KEGG; ddi:DDB_G0275853; -.
DR dictyBase; DDB_G0275853; -.
DR eggNOG; ENOG502QSIA; Eukaryota.
DR HOGENOM; CLU_019631_1_0_1; -.
DR InParanoid; Q8MXQ3; -.
DR OMA; KAPNDPQ; -.
DR PhylomeDB; Q8MXQ3; -.
DR PRO; PR:Q8MXQ3; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR021280; DUF2723.
DR Pfam; PF11028; DUF2723; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..819
FT /note="Transmembrane protein 260 homolog"
FT /id="PRO_0000356837"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 459..479
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 505..525
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 70
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 349
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 531
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 686
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 693
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 783
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 819 AA; 94520 MW; 30F8EDCE6D0E462E CRC64;
MNNSPTLSNT RNRKNNNNNS NSNSNSNNNN NNNNNNNNNS NNNNNNNNNV NRNVNNRNNN
NNNIINVNNN VSSTTMNMAK DFMNWNDGII EREDTQLQQQ KDRCFKILKK STIACIVLLF
ISCTIIYSMT QYPSVSGGDA GELIVVAHQF GVAHPPGYPL FTFLGYIFSH IIPSNTLSVA
WKISFMSSMI GSIASIFIYL TVYLWVNNHW CGLLSAYMFT FSPLIWMYQI QGEVFSMNNM
FVAMLMFLGV WYTRVRIFEN ERYNTAFWTS ERIAYLSAFS CAIGLTNQHT LVLIVIPFAF
WLMFISGRDQ LWNIKILSNL VFYTLIGLSP YLLLFITPKL NRVKYSWGNT STLRGFIKHF
LREEYGTLQL YGGDGGVISL FTKISIYIEN LIIQFGYIGL ALSLIGLLNL LLGYNIRTFK
WKSFGTMIIF SFLFYITFFF NLCNLPIDKP LYRGVFLRFF MQPNVIISIT MGLGIKSIFG
FLNRIQRDGG TAATTTTTIS KIQKYLLPII IILLVGNQIG FNYNLQDQSD NYSFYDYGHS
VLDGLPRNTL LLVGGDLVTN VPMYLHLCEK VRPDIDILSM EIMSWEWFKI TQSPLFQRVK
FPGNVYHPYI PDGYSLKDFL DANINDRPIY IGGDFKSGDS SFQNDYYTIS KGLTSQIIPK
KDSHKFNTFK IIKTTFSTFP SFHIPNNTEK YPNDSWEHFM MEEMAVSLER AAETLLKEYL
SQQNTESFKA LELSVEILEK ALTYVNDKCW SLKHLGICFD HLRYRVVQNV NNNNQQAQNK
ASNYSKQLLY FWKKYINQCT HEENTDQDWE TIKKVIQLI
