TM260_MOUSE
ID TM260_MOUSE Reviewed; 703 AA.
AC Q8BMD6; Q6GT69; Q80SZ4; Q8BMG3; Q8BW28; Q8BYU4;
DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 24-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Transmembrane protein 260;
GN Name=Tmem260;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Forelimb, Mesonephros, and Ovary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 41-703 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9NX78}; Multi-
CC pass membrane protein {ECO:0000305}. Note=Shows strong localization in
CC the vicinity of the cell membrane. {ECO:0000250|UniProtKB:Q9NX78}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BMD6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BMD6-2; Sequence=VSP_008622;
CC -!- SIMILARITY: Belongs to the TMEM260 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH59217.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC28033.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC35803.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK031240; BAC27314.1; -; mRNA.
DR EMBL; AK032809; BAC28033.1; ALT_INIT; mRNA.
DR EMBL; AK054494; BAC35803.1; ALT_INIT; mRNA.
DR EMBL; BC046454; AAH46454.1; -; mRNA.
DR EMBL; BC046491; AAH46491.1; -; mRNA.
DR EMBL; BC059217; AAH59217.1; ALT_INIT; mRNA.
DR CCDS; CCDS26993.2; -. [Q8BMD6-1]
DR CCDS; CCDS79318.1; -. [Q8BMD6-2]
DR RefSeq; NP_001297513.1; NM_001310584.1. [Q8BMD6-2]
DR RefSeq; NP_766188.3; NM_172600.4. [Q8BMD6-1]
DR AlphaFoldDB; Q8BMD6; -.
DR SMR; Q8BMD6; -.
DR STRING; 10090.ENSMUSP00000107364; -.
DR iPTMnet; Q8BMD6; -.
DR PhosphoSitePlus; Q8BMD6; -.
DR EPD; Q8BMD6; -.
DR MaxQB; Q8BMD6; -.
DR PaxDb; Q8BMD6; -.
DR PeptideAtlas; Q8BMD6; -.
DR PRIDE; Q8BMD6; -.
DR ProteomicsDB; 260695; -. [Q8BMD6-1]
DR ProteomicsDB; 260696; -. [Q8BMD6-2]
DR Antibodypedia; 185; 46 antibodies from 17 providers.
DR DNASU; 218989; -.
DR Ensembl; ENSMUST00000111735; ENSMUSP00000107364; ENSMUSG00000036339. [Q8BMD6-1]
DR Ensembl; ENSMUST00000124720; ENSMUSP00000118376; ENSMUSG00000036339. [Q8BMD6-2]
DR GeneID; 218989; -.
DR KEGG; mmu:218989; -.
DR UCSC; uc007tjk.2; mouse. [Q8BMD6-1]
DR CTD; 54916; -.
DR MGI; MGI:2443219; Tmem260.
DR VEuPathDB; HostDB:ENSMUSG00000036339; -.
DR eggNOG; ENOG502QSIA; Eukaryota.
DR GeneTree; ENSGT00390000013544; -.
DR HOGENOM; CLU_019631_2_0_1; -.
DR InParanoid; Q8BMD6; -.
DR OrthoDB; 600216at2759; -.
DR PhylomeDB; Q8BMD6; -.
DR TreeFam; TF329604; -.
DR BioGRID-ORCS; 218989; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Tmem260; mouse.
DR PRO; PR:Q8BMD6; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q8BMD6; protein.
DR Bgee; ENSMUSG00000036339; Expressed in retinal neural layer and 101 other tissues.
DR ExpressionAtlas; Q8BMD6; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR021280; DUF2723.
DR Pfam; PF11028; DUF2723; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..703
FT /note="Transmembrane protein 260"
FT /id="PRO_0000089906"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..152
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_008622"
FT CONFLICT 535
FT /note="W -> R (in Ref. 1; BAC27314)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 703 AA; 78947 MW; 9D3E8979276A9D12 CRC64;
MGLHGDGGSP AAGAGPWRSG ALRGSVAVFA SVAAVFTLTL PRSLPGGDSG ELITAAHELG
VAHPPGYPLF TLLASLTITL FPFGSVAYRV NLLCGLFGAV AASLLFYTVF RLSGSHAGGI
LAAGVFSFSR LTWQWSIAAE VFSLNNLFVG LLMALTVRFE EATAAKERSK IAAIGAFSCG
LSLCNQHTIV LYILCIIPWI LFRLLKEKEL TLSLLLRLTL AFSAGLLPYV YLPVSSYLSR
ARWTWGDQTT LRGFLTHFFR EEYGTFSLAK SEVGSSVSTV LLSQVINMKT ELSFNIQALA
VWANICLARK DRRKSSVVWL FTGMLCLYSL FFAWRANLDI SKPLFMGVVE RFWLQSNAVV
AVLAGLGLAT LVSETNRVLH CTGIRNLEWL SAALFVAYQV YSNYSICDQR TNNVIDQFAR
NLLDSMPQDA IILLRGDLPG NALRYLHYCE GLRPDVSLVD QEMMTYEWYL PKMARHLPGV
HFPGDRWNPV EGVLPSGMVT FNLYHFLEMN KQKETFVCIG IHEGDPTWKK DYSLWPWGSC
DKLVPSKIVF NPEEWIERTR AIYNWTEAYE RFGPSSWESV ANEEMWQARM KTPFFIFSLA
ESAAVPADVK AQLYTHAYKL YKEIVYLQEE HPVNWHKNYA IACERMLRLP GTGIDPEVLL
SEAIRHFHLY TQKAQNDPQR ADIIAALKHL RRELQSLRNI KKV
