ID   TM263_CHICK             Reviewed;         116 AA.
AC   Q5ZLA9;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Transmembrane protein 263;
GN   Name=TMEM263; ORFNames=RCJMB04_6o13;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
RN   [2]
RP   VARIANT 59-TRP--ASP-116 DEL, AND PROBABLE INVOLVEMENT IN DWARFISM.
RX   PubMed=29930570; DOI=10.3389/fgene.2018.00193;
RA   Wu Z., Derks M.F.L., Dibbits B., Megens H.J., Groenen M.A.M.,
RA   Crooijmans R.P.M.A.;
RT   "A Novel Loss-of-Function Variant in Transmembrane Protein 263 (TMEM263) of
RT   Autosomal Dwarfism in Chicken.";
RL   Front. Genet. 9:193-193(2018).
CC   -!- FUNCTION: May be involved in the growth pathway.
CC       {ECO:0000269|PubMed:29930570}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- DISEASE: Note=Defect in TMEM263 may be a one of the causes of autosomal
CC       recessive dwarfism in Cornell K-strain white leghorns. A nonsense
CC       mutation truncates the protein and probably cause a dysfunctional
CC       protein. Autosomal dwarf chicken display small body stature by short
CC       shank length, with 30-40% reduced adult body weight despite normal
CC       hormonal concentration of GH and IGF1. {ECO:0000269|PubMed:29930570}.
CC   -!- SIMILARITY: Belongs to the TMEM263 family. {ECO:0000305}.
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DR   EMBL; AJ719825; CAG31484.1; -; mRNA.
DR   RefSeq; NP_001006244.1; NM_001006244.1.
DR   AlphaFoldDB; Q5ZLA9; -.
DR   STRING; 9031.ENSGALP00000020600; -.
DR   PaxDb; Q5ZLA9; -.
DR   GeneID; 418068; -.
DR   KEGG; gga:418068; -.
DR   CTD; 90488; -.
DR   VEuPathDB; HostDB:geneid_418068; -.
DR   eggNOG; ENOG502S1YC; Eukaryota.
DR   InParanoid; Q5ZLA9; -.
DR   OrthoDB; 1600476at2759; -.
DR   PhylomeDB; Q5ZLA9; -.
DR   PRO; PR:Q5ZLA9; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR028153; UPF0444.
DR   PANTHER; PTHR31443; PTHR31443; 1.
DR   Pfam; PF15475; UPF0444; 1.
PE   3: Inferred from homology;
KW   Dwarfism; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..116
FT                   /note="Transmembrane protein 263"
FT                   /id="PRO_0000263631"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        2
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         59..116
FT                   /note="Missing"
FT                   /evidence="ECO:0000269|PubMed:29930570"
SQ   SEQUENCE   116 AA;  11712 MW;  E5F177CE4FD90F83 CRC64;
     MNQTDKSHQE VPSYLHDEPP EGSIKDHPQQ QPSMLSRVTG GIFSVTKGAV GATIGGVAWI
     GGKSLEITKT AVTSVPSMGV GLVKGSVSAV AGGVTAVGSA VASKVPLTGK KKDKSD