ID   TM263_MOUSE             Reviewed;         115 AA.
AC   Q9DAM7;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Transmembrane protein 263;
GN   Name=Tmem263;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Eye, and Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Lung, Pancreas, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May play a role in bone development.
CC       {ECO:0000250|UniProtKB:Q8WUH6}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the TMEM263 family. {ECO:0000305}.
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DR   EMBL; AK005698; BAB24195.1; -; mRNA.
DR   EMBL; AK142035; BAE24921.1; -; mRNA.
DR   EMBL; BC086492; AAH86492.1; -; mRNA.
DR   CCDS; CCDS24087.1; -.
DR   RefSeq; NP_001013046.1; NM_001013028.2.
DR   AlphaFoldDB; Q9DAM7; -.
DR   BioGRID; 222049; 1.
DR   STRING; 10090.ENSMUSP00000093030; -.
DR   iPTMnet; Q9DAM7; -.
DR   PhosphoSitePlus; Q9DAM7; -.
DR   SwissPalm; Q9DAM7; -.
DR   EPD; Q9DAM7; -.
DR   MaxQB; Q9DAM7; -.
DR   PaxDb; Q9DAM7; -.
DR   PeptideAtlas; Q9DAM7; -.
DR   PRIDE; Q9DAM7; -.
DR   ProteomicsDB; 259558; -.
DR   Antibodypedia; 48264; 49 antibodies from 11 providers.
DR   DNASU; 103266; -.
DR   Ensembl; ENSMUST00000095383; ENSMUSP00000093030; ENSMUSG00000060935.
DR   Ensembl; ENSMUST00000216771; ENSMUSP00000149447; ENSMUSG00000060935.
DR   GeneID; 103266; -.
DR   KEGG; mmu:103266; -.
DR   UCSC; uc007glb.2; mouse.
DR   CTD; 90488; -.
DR   MGI; MGI:2143652; Tmem263.
DR   VEuPathDB; HostDB:ENSMUSG00000060935; -.
DR   eggNOG; ENOG502S1YC; Eukaryota.
DR   GeneTree; ENSGT00390000013899; -.
DR   HOGENOM; CLU_131259_1_0_1; -.
DR   InParanoid; Q9DAM7; -.
DR   OMA; EDMPAYH; -.
DR   OrthoDB; 1600476at2759; -.
DR   PhylomeDB; Q9DAM7; -.
DR   TreeFam; TF333298; -.
DR   BioGRID-ORCS; 103266; 0 hits in 71 CRISPR screens.
DR   ChiTaRS; Tmem263; mouse.
DR   PRO; PR:Q9DAM7; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; Q9DAM7; protein.
DR   Bgee; ENSMUSG00000060935; Expressed in humerus cartilage element and 221 other tissues.
DR   Genevisible; Q9DAM7; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR028153; UPF0444.
DR   PANTHER; PTHR31443; PTHR31443; 1.
DR   Pfam; PF15475; UPF0444; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..115
FT                   /note="Transmembrane protein 263"
FT                   /id="PRO_0000263630"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   115 AA;  11549 MW;  4C3E54AFD5199F59 CRC64;
     MNQADKNQEI PSYLSDEPPE GSMKDHPQQQ PGMLSRVTGG IFSVTKGAVG ATIGGVAWIG
     GKSLEVTKTA VTTVPSMGIG LVKGGVSAVA GGVTAVGSAV VNKVPLSGKK KDKSD