ID   TM265_HUMAN             Reviewed;         108 AA.
AC   A0A087WTH1;
DT   01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   29-OCT-2014, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Transmembrane protein 265 {ECO:0000312|HGNC:HGNC:51241};
GN   Name=TMEM265 {ECO:0000312|HGNC:HGNC:51241};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA   Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA   Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA   Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA   Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA   Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA   Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA   Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA   Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA   Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA   Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA   Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA   Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA   Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA   Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA   Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA   Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA   DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA   Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA   Myers R.M., Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the CD225/Dispanin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC106886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471192; EAW52212.1; -; Genomic_DNA.
DR   CCDS; CCDS73870.1; -.
DR   RefSeq; NP_001243758.1; NM_001256829.1.
DR   AlphaFoldDB; A0A087WTH1; -.
DR   BioMuta; TMEM265; -.
DR   jPOST; A0A087WTH1; -.
DR   PeptideAtlas; A0A087WTH1; -.
DR   DNASU; 100862671; -.
DR   Ensembl; ENST00000615541.3; ENSP00000477871.1; ENSG00000281991.2.
DR   GeneID; 100862671; -.
DR   KEGG; hsa:100862671; -.
DR   MANE-Select; ENST00000615541.3; ENSP00000477871.1; NM_001256829.2; NP_001243758.1.
DR   UCSC; uc031qvt.2; human.
DR   CTD; 100862671; -.
DR   GeneCards; TMEM265; -.
DR   HGNC; HGNC:51241; TMEM265.
DR   HPA; ENSG00000281991; Low tissue specificity.
DR   neXtProt; NX_A0A087WTH1; -.
DR   VEuPathDB; HostDB:ENSG00000281991; -.
DR   GeneTree; ENSGT00960000186703; -.
DR   HOGENOM; CLU_2183080_0_0_1; -.
DR   OMA; SFAVWFA; -.
DR   OrthoDB; 1623652at2759; -.
DR   PathwayCommons; A0A087WTH1; -.
DR   BioGRID-ORCS; 100862671; 13 hits in 173 CRISPR screens.
DR   Pharos; A0A087WTH1; Tdark.
DR   PRO; PR:A0A087WTH1; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; A0A087WTH1; protein.
DR   Bgee; ENSG00000281991; Expressed in lower esophagus mucosa and 73 other tissues.
DR   Genevisible; A0A087WTH1; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007593; CD225/Dispanin_fam.
DR   Pfam; PF04505; CD225; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..108
FT                   /note="Transmembrane protein 265"
FT                   /id="PRO_0000432548"
FT   TRANSMEM        34..54
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   108 AA;  11832 MW;  9067BA109EC2F2CC CRC64;
     MEDEEKAVEI LGNTEAAHPP SPIRCCWLRL RCLAATSIIC GCSCLGVMAL VFAIKAEERH
     KAGRSEEAVR WGARARKLIL ASFAVWLAVL ILGPLLLWLL SYAIAQAE