ID   TM266_MACFA             Reviewed;         531 AA.
AC   Q9N0B5; G8F4X6;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-MAY-2019, sequence version 3.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Transmembrane protein 266 {ECO:0000305};
GN   Name=TMEM266 {ECO:0000250|UniProtKB:Q2M3C6};
GN   ORFNames=EGM_20651 {ECO:0000303|PubMed:22002653},
GN   QccE-15063 {ECO:0000250|UniProtKB:Q2M3C6};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N., Li Q.,
RA   Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P., Huang Z.,
RA   Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T., Huang Y.,
RA   Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D., Li B., Liu X.,
RA   Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X., Li Y., Wang W.,
RA   Katze M.G., Su B., Nielsen R., Yang H., Wang J., Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal models,
RT   the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 114-531.
RC   TISSUE=Brain cortex;
RX   PubMed=11574149; DOI=10.1016/s0378-1119(01)00665-5;
RA   Osada N., Hida M., Kususda J., Tanuma R., Iseki K., Hirata M., Suto Y.,
RA   Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K.;
RT   "Assignment of 118 novel cDNAs of cynomolgus monkey brain to human
RT   chromosomes.";
RL   Gene 275:31-37(2001).
RN   [3]
RP   ERRATUM OF PUBMED:11574149.
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirata M., Suto Y.,
RA   Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K., Kususda J.;
RL   Gene 278:267-267(2001).
CC   -!- FUNCTION: Voltage-sensor protein present on the post-synaptic side of
CC       glutamatergic mossy fibers and granule cells in the cerebellum. Despite
CC       the presence of a voltage-sensor segment, does not form a functional
CC       ion channel and its precise role remains unclear. Undergoes both rapid
CC       and slow structural rearrangements in response to changes in voltage.
CC       Contains a zinc-binding site that can regulate the slow conformational
CC       transition. {ECO:0000250|UniProtKB:Q2M3C6}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250|UniProtKB:Q2M3C6}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q2M3C6};
CC       Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite
CC       {ECO:0000250|UniProtKB:Q2M3C6}. Perikaryon
CC       {ECO:0000250|UniProtKB:Q2M3C6}. Note=Present in the dendrites and soma
CC       of cerebellar granule neurons, but not in their axon.
CC       {ECO:0000250|UniProtKB:Q2M3C6}.
CC   -!- DOMAIN: The transmembrane segment S4 functions as voltage-sensor and is
CC       characterized by a series of positively charged amino acids at every
CC       third position. Transplantation of the transmembrane segment S4 into
CC       HVCN1, generates a functional voltage-activated proton channel.
CC       {ECO:0000250|UniProtKB:Q2M3C6}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB01597.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; JH331148; EHH62340.1; -; Genomic_DNA.
DR   EMBL; AQIA01063333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB046015; BAB01597.1; ALT_INIT; mRNA.
DR   RefSeq; XP_005560206.1; XM_005560149.2.
DR   RefSeq; XP_015308606.1; XM_015453120.1.
DR   RefSeq; XP_015308607.1; XM_015453121.1.
DR   RefSeq; XP_015308608.1; XM_015453122.1.
DR   AlphaFoldDB; Q9N0B5; -.
DR   STRING; 9541.XP_005560206.1; -.
DR   GeneID; 101926642; -.
DR   KEGG; mcf:101926642; -.
DR   CTD; 123591; -.
DR   VEuPathDB; HostDB:ENSMFAG00000027682; -.
DR   eggNOG; ENOG502QRI0; Eukaryota.
DR   OMA; PAREDDM; -.
DR   OrthoDB; 826861at2759; -.
DR   Proteomes; UP000009130; Unassembled WGS sequence.
DR   Proteomes; UP000233100; Chromosome 7.
DR   GO; GO:0030425; C:dendrite; ISS:UniProtKB.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   Gene3D; 1.20.120.350; -; 1.
DR   InterPro; IPR042857; TMEM266.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR46842; PTHR46842; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Coiled coil; Disulfide bond; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..531
FT                   /note="Transmembrane protein 266"
FT                   /id="PRO_0000244095"
FT   TOPO_DOM        1..102
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        103..123
FT                   /note="Helical; Name=Segment S1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        124..129
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        130..150
FT                   /note="Helical; Name=Segment S2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        151..169
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        170..190
FT                   /note="Helical; Name=Segment S3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        191..199
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        200..220
FT                   /note="Helical; Name=Segment S4"
FT                   /evidence="ECO:0000250|UniProtKB:Q2M3C6"
FT   TOPO_DOM        221..531
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   REGION          380..477
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          231..251
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        381..419
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        432..452
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        404
FT                   /note="T -> M (in Ref. 2; BAB01597)"
SQ   SEQUENCE   531 AA;  58368 MW;  81299048F350CD65 CRC64;
     MALAASFNMT NPQPAIEGGI SEVEIISQQV DEETKSIAPV QLVNFAYRDL PLAAVDLSTA
     GSQLLSNLDE DYQREGSNWL KPCCGKRAAV WQVFLLSASL NSFLVACVIL VVILLTLELL
     IDIKLLQFSS AFQFAGVIHW ISLVILSVFF SETVLRIVVL GIWDYIENKI EVFDGAVIIL
     SLAPMVASTV ANGPRSPWDA ISLIIMLRIW RVKRVIDAYV LPVKLEMEMV IQQYEKAKVI
     QDEQLERLTQ ICQEQGFEIR QLRAHLAQQD LDLAAEREAA LQAPHVLSQP RSRFKVVEAG
     TWEEETAAES VVEELQPSQE AMVKDDMNSY ISQYYNGPSS DSGVPDAAVC MVTTAAIDIH
     QPDISSDLFS LDMPLKLGGN GTGATSESAS RSSVTRAQSD SSQTLGSSTD CSTAREEPSS
     EPGPSPLPLP PQQQVEEATV QDLLSSLSED PCPSQRALDP APLSRPSPAG SAQTSPELEH
     RVSLFNQKNQ EGFTVFQIRP VIHFQPTVPV LEDKFRSLES KEQKLHRVPE A