TM267_HUMAN
ID TM267_HUMAN Reviewed; 215 AA.
AC Q0VDI3; B2RDA6; Q9H6Z2;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Transmembrane protein 267 {ECO:0000312|HGNC:HGNC:26139};
GN Name=TMEM267 {ECO:0000312|HGNC:HGNC:26139}; Synonyms=C5orf28;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lymph, and PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q0VDI3; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-17555467, EBI-18013275;
CC Q0VDI3; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-17555467, EBI-10244780;
CC Q0VDI3; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-17555467, EBI-3920694;
CC Q0VDI3; O15400: STX7; NbExp=3; IntAct=EBI-17555467, EBI-3221827;
CC Q0VDI3; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-17555467, EBI-8638294;
CC Q0VDI3; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-17555467, EBI-18178701;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK025310; BAB15108.1; -; mRNA.
DR EMBL; AK315466; BAG37853.1; -; mRNA.
DR EMBL; CH471119; EAW56061.1; -; Genomic_DNA.
DR EMBL; BC063832; AAH63832.1; -; mRNA.
DR EMBL; BC013351; AAH13351.1; -; mRNA.
DR EMBL; BC119658; AAI19659.1; -; mRNA.
DR EMBL; BC119659; AAI19660.1; -; mRNA.
DR CCDS; CCDS3945.1; -.
DR RefSeq; NP_071928.2; NM_022483.4.
DR RefSeq; XP_005248390.1; XM_005248333.4.
DR RefSeq; XP_005248392.1; XM_005248335.3.
DR RefSeq; XP_006714549.1; XM_006714486.3.
DR RefSeq; XP_011512376.1; XM_011514074.2.
DR RefSeq; XP_011512377.1; XM_011514075.2.
DR AlphaFoldDB; Q0VDI3; -.
DR BioGRID; 122166; 15.
DR IntAct; Q0VDI3; 9.
DR STRING; 9606.ENSP00000426067; -.
DR BioMuta; TMEM267; -.
DR DMDM; 121940485; -.
DR EPD; Q0VDI3; -.
DR jPOST; Q0VDI3; -.
DR MassIVE; Q0VDI3; -.
DR MaxQB; Q0VDI3; -.
DR PaxDb; Q0VDI3; -.
DR PeptideAtlas; Q0VDI3; -.
DR PRIDE; Q0VDI3; -.
DR ProteomicsDB; 58829; -.
DR Antibodypedia; 67211; 33 antibodies from 9 providers.
DR DNASU; 64417; -.
DR Ensembl; ENST00000397080.8; ENSP00000380270.3; ENSG00000151881.15.
DR Ensembl; ENST00000500337.6; ENSP00000426067.1; ENSG00000151881.15.
DR Ensembl; ENST00000512085.5; ENSP00000422881.1; ENSG00000151881.15.
DR GeneID; 64417; -.
DR KEGG; hsa:64417; -.
DR MANE-Select; ENST00000397080.8; ENSP00000380270.3; NM_022483.5; NP_071928.2.
DR UCSC; uc003jnv.5; human.
DR CTD; 64417; -.
DR DisGeNET; 64417; -.
DR GeneCards; TMEM267; -.
DR HGNC; HGNC:26139; TMEM267.
DR HPA; ENSG00000151881; Tissue enhanced (thyroid).
DR neXtProt; NX_Q0VDI3; -.
DR OpenTargets; ENSG00000151881; -.
DR PharmGKB; PA162380004; -.
DR VEuPathDB; HostDB:ENSG00000151881; -.
DR eggNOG; ENOG502QQ1U; Eukaryota.
DR GeneTree; ENSGT00390000003050; -.
DR InParanoid; Q0VDI3; -.
DR OMA; FYICTAC; -.
DR OrthoDB; 1326580at2759; -.
DR PhylomeDB; Q0VDI3; -.
DR TreeFam; TF323520; -.
DR PathwayCommons; Q0VDI3; -.
DR SignaLink; Q0VDI3; -.
DR BioGRID-ORCS; 64417; 5 hits in 1063 CRISPR screens.
DR ChiTaRS; TMEM267; human.
DR GenomeRNAi; 64417; -.
DR Pharos; Q0VDI3; Tdark.
DR PRO; PR:Q0VDI3; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q0VDI3; protein.
DR Bgee; ENSG00000151881; Expressed in islet of Langerhans and 160 other tissues.
DR ExpressionAtlas; Q0VDI3; baseline and differential.
DR Genevisible; Q0VDI3; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026572; TMEM267.
DR PANTHER; PTHR13628; PTHR13628; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..215
FT /note="Transmembrane protein 267"
FT /id="PRO_0000281921"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 86
FT /note="L -> F (in Ref. 1; BAB15108)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 215 AA; 24217 MW; 7E18288823B3BDE6 CRC64;
MASETEKTHA LLQTCSTESL ISSLGLGAFC LVADRLLQFS TIQQNDWLRA LSDNAVHCVI
GMWSWAVVTG IKKKTDFGEI ILAGFLASVI DVDHFFLAGS MSLKAALTLP RRPFLHCSTV
IPVVVLTLKF TMHLFKLKDS WCFLPWMLFI SWTSHHIRDG IRHGLWICPF GKTSPLPFWL
YVIITSSLPH ICSFVMYLTG TRQMMSSKHG VRIDV
