TM268_MOUSE
ID TM268_MOUSE Reviewed; 342 AA.
AC Q8R239; Q3TTV3; Q3UMC5; Q80VW1; Q80VW2; Q8BMN2; Q8C0I7; Q8CIJ7;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Transmembrane protein 268 {ECO:0000312|MGI:MGI:1913920};
GN Name=Tmem268 {ECO:0000312|MGI:MGI:1913920};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Pituitary, Skin, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Liver, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8R239-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8R239-2; Sequence=VSP_023429, VSP_023430;
CC Name=3;
CC IsoId=Q8R239-3; Sequence=VSP_023428;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH23748.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAD62270.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAD62271.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK030466; BAC26975.1; -; mRNA.
DR EMBL; AK031016; BAC27214.1; -; mRNA.
DR EMBL; AK144990; BAE26173.1; -; mRNA.
DR EMBL; AK161160; BAE36221.1; -; mRNA.
DR EMBL; AL691484; CAD62270.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL691484; CAD62271.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL691484; CAD62272.1; -; Genomic_DNA.
DR EMBL; BC022599; AAH22599.2; -; mRNA.
DR EMBL; BC023748; AAH23748.1; ALT_FRAME; mRNA.
DR CCDS; CCDS18261.1; -. [Q8R239-1]
DR RefSeq; NP_659154.2; NM_144905.3. [Q8R239-1]
DR RefSeq; XP_006537929.1; XM_006537866.2.
DR RefSeq; XP_006537930.1; XM_006537867.2. [Q8R239-1]
DR RefSeq; XP_006537931.1; XM_006537868.3. [Q8R239-1]
DR RefSeq; XP_006537932.1; XM_006537869.1. [Q8R239-1]
DR RefSeq; XP_006537933.1; XM_006537870.3. [Q8R239-1]
DR RefSeq; XP_006537934.1; XM_006537871.3. [Q8R239-1]
DR RefSeq; XP_006537935.1; XM_006537872.3. [Q8R239-1]
DR RefSeq; XP_006537936.1; XM_006537873.3. [Q8R239-1]
DR RefSeq; XP_011248311.1; XM_011250009.2.
DR AlphaFoldDB; Q8R239; -.
DR STRING; 10090.ENSMUSP00000076891; -.
DR PhosphoSitePlus; Q8R239; -.
DR MaxQB; Q8R239; -.
DR PaxDb; Q8R239; -.
DR PeptideAtlas; Q8R239; -.
DR PRIDE; Q8R239; -.
DR ProteomicsDB; 259109; -. [Q8R239-1]
DR ProteomicsDB; 259110; -. [Q8R239-2]
DR ProteomicsDB; 259111; -. [Q8R239-3]
DR Antibodypedia; 15584; 87 antibodies from 16 providers.
DR DNASU; 230279; -.
DR Ensembl; ENSMUST00000077709; ENSMUSP00000076891; ENSMUSG00000045917. [Q8R239-1]
DR Ensembl; ENSMUST00000080336; ENSMUSP00000079211; ENSMUSG00000045917. [Q8R239-1]
DR GeneID; 230279; -.
DR KEGG; mmu:230279; -.
DR UCSC; uc008tgs.1; mouse. [Q8R239-1]
DR CTD; 203197; -.
DR MGI; MGI:1913920; Tmem268.
DR VEuPathDB; HostDB:ENSMUSG00000045917; -.
DR eggNOG; ENOG502R635; Eukaryota.
DR GeneTree; ENSGT00390000011559; -.
DR HOGENOM; CLU_067585_1_0_1; -.
DR InParanoid; Q8R239; -.
DR OMA; VPCPCQF; -.
DR OrthoDB; 868229at2759; -.
DR PhylomeDB; Q8R239; -.
DR TreeFam; TF353168; -.
DR BioGRID-ORCS; 230279; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q8R239; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8R239; protein.
DR Bgee; ENSMUSG00000045917; Expressed in substantia nigra and 203 other tissues.
DR ExpressionAtlas; Q8R239; baseline and differential.
DR Genevisible; Q8R239; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028054; DUF4481.
DR PANTHER; PTHR31193; PTHR31193; 1.
DR Pfam; PF14800; DUF4481; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..342
FT /note="Transmembrane protein 268"
FT /id="PRO_0000279426"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 245..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..60
FT /note="MACEPPTDPGGAAGPLPTSTLGCNILPQGNPPGWGQELHNGQVLTVLRIDNT
FT CAPISFDL -> MARSSQSSGSTIPVHLSPLTW (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_023428"
FT VAR_SEQ 160..204
FT /note="ANTNTDLRLVAANGALLRHRVLLGVTDTVEGCQSVIQLWFVYFDL -> EAG
FT VFPPPYTRSRDRPGKTQQTRIFCGKTLLLTSSGASVQAPNPK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_023429"
FT VAR_SEQ 205..342
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_023430"
FT CONFLICT 25..26
FT /note="IL -> TM (in Ref. 1; BAE26173)"
FT /evidence="ECO:0000305"
FT CONFLICT 119
FT /note="I -> M (in Ref. 1; BAC26975)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 342 AA; 37763 MW; 153D059A1DCD6D82 CRC64;
MACEPPTDPG GAAGPLPTST LGCNILPQGN PPGWGQELHN GQVLTVLRID NTCAPISFDL
GAAEEQLQAW GIQVPAEQYR NLAESALLEP QVRRYIIYNS RPMRLAFAVV FYVLVWANIY
STSQMFALGN QWAGVLLATL AAFSLTLTLV LVFERQQRKA NTNTDLRLVA ANGALLRHRV
LLGVTDTVEG CQSVIQLWFV YFDLENCVQF LSDHVQEMKR SQESLLRSRL SQLCVVMETG
VSPVVEGPED LEDAPLLPST PGPQERPLTQ TELYQLVPEA EPEEMARQLL AVFGGYYTRL
LVTSRLPQSM GTRHMDSARI PCPCQLIEVH VLGTGCCPFL AR
