ID   TM269_HUMAN             Reviewed;         245 AA.
AC   A0A1B0GVZ9;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2016, sequence version 1.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=Transmembrane protein 269 {ECO:0000312|HGNC:HGNC:52381};
GN   Name=TMEM269 {ECO:0000312|HGNC:HGNC:52381};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC098484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL512353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001229679.1; NM_001242750.1.
DR   AlphaFoldDB; A0A1B0GVZ9; -.
DR   SMR; A0A1B0GVZ9; -.
DR   BioMuta; TMEM269; -.
DR   PeptideAtlas; A0A1B0GVZ9; -.
DR   Ensembl; ENST00000536543.6; ENSP00000490716.2; ENSG00000274386.6.
DR   GeneCards; TMEM269; -.
DR   HGNC; HGNC:52381; TMEM269.
DR   HPA; ENSG00000274386; Tissue enhanced (brain, retina).
DR   neXtProt; NX_A0A1B0GVZ9; -.
DR   VEuPathDB; HostDB:ENSG00000274386; -.
DR   OMA; ASFRLCF; -.
DR   BioGRID-ORCS; 100129924; 9 hits in 157 CRISPR screens.
DR   GenomeRNAi; 100129924; -.
DR   Pharos; A0A1B0GVZ9; Tdark.
DR   PRO; PR:A0A1B0GVZ9; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; A0A1B0GVZ9; protein.
DR   Bgee; ENSG00000274386; Expressed in thymus and 99 other tissues.
DR   ExpressionAtlas; A0A1B0GVZ9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..245
FT                   /note="Transmembrane protein 269"
FT                   /id="PRO_0000440585"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   245 AA;  26874 MW;  4C0152E8AE8F0A40 CRC64;
     MGEGPHTPCI LGHGASGDHD QSHSQINEVS WKDVTSALSL ANMVLGLFSI IFSFSRKCHY
     ASRMLLVSFL LDMAVRAMTS HINICSKLGA ELNDFAVFTT FGLASALLLG VDGLLSGILA
     IIYVSAASFH LCFYSPGVPS TYKGLPCPYA SCILASTSLL TKGNRFILCC MASLMILFMM
     DQSYYPYDKI LESENWKKLV YIGGVIMLFF SPLSLSAFYC LMWSLSYIFF PDALWGKAAC
     LSPQH