TM269_MOUSE
ID TM269_MOUSE Reviewed; 254 AA.
AC Q9D4Y8;
DT 07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Transmembrane protein 269 {ECO:0000312|MGI:MGI:1922430};
GN Name=Tmem269 {ECO:0000312|MGI:MGI:1922430};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
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DR EMBL; AK015991; BAB30070.1; -; mRNA.
DR EMBL; AK053970; BAC35606.1; -; mRNA.
DR EMBL; AL606975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS18574.1; -.
DR RefSeq; NP_083474.1; NM_029198.3.
DR AlphaFoldDB; Q9D4Y8; -.
DR SMR; Q9D4Y8; -.
DR STRING; 10090.ENSMUSP00000030394; -.
DR PaxDb; Q9D4Y8; -.
DR PRIDE; Q9D4Y8; -.
DR Ensembl; ENSMUST00000212054; ENSMUSP00000148286; ENSMUSG00000028642.
DR GeneID; 75180; -.
DR KEGG; mmu:75180; -.
DR UCSC; uc008ulm.1; mouse.
DR CTD; 100129924; -.
DR MGI; MGI:1922430; Tmem269.
DR VEuPathDB; HostDB:ENSMUSG00000028642; -.
DR eggNOG; ENOG502QRZI; Eukaryota.
DR GeneTree; ENSGT00940000154169; -.
DR HOGENOM; CLU_081147_0_0_1; -.
DR InParanoid; Q9D4Y8; -.
DR OMA; ASFRLCF; -.
DR OrthoDB; 988114at2759; -.
DR PhylomeDB; Q9D4Y8; -.
DR TreeFam; TF332358; -.
DR BioGRID-ORCS; 75180; 3 hits in 69 CRISPR screens.
DR ChiTaRS; Tmem269; mouse.
DR PRO; PR:Q9D4Y8; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9D4Y8; protein.
DR Bgee; ENSMUSG00000028642; Expressed in testis and 30 other tissues.
DR ExpressionAtlas; Q9D4Y8; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..254
FT /note="Transmembrane protein 269"
FT /id="PRO_0000440586"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 254 AA; 28198 MW; 929722D37942495C CRC64;
MLGTGDPNLH SSCILSRKKG RQGHHIMKHE QIGSQMTEFS WKDIINALAL ANMILGLFSI
FCSFSRKSYC ASWMLLISFL LDIAIGTMTK HLNIPHKLGL ELNDFAIFTT FGLASALLLG
VDGPLNGFLA IIYVLTTSFR MCFYSTGGAT SGYKGLPCPY ASCVLASTCL LTKGNTFILC
CMASLMILFM IDQSCYPHDE ILDSDNWKKI VYIGGVILLF FSPFPLTAFY CLTWSLSYIF
SPETLWGRGV RIKP
