TM270_MOUSE
ID TM270_MOUSE Reviewed; 264 AA.
AC Q6UJB9; Q9D9B5;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Transmembrane protein 270 {ECO:0000305};
GN Name=Tmem270 {ECO:0000250|UniProtKB:Q6UE05};
GN Synonyms=Wbscr28 {ECO:0000312|MGI:MGI:1923879};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND TISSUE SPECIFICITY.
RX PubMed=18398435; DOI=10.1038/ejhg.2008.68;
RA Micale L., Fusco C., Augello B., Napolitano L.M.R., Dermitzakis E.T.,
RA Meroni G., Merla G., Reymond A.;
RT "Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase.";
RL Eur. J. Hum. Genet. 16:1038-1049(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=129;
RX PubMed=14656967; DOI=10.1101/gr.1736803;
RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D.,
RA Hood L.;
RT "Analysis of the gene-dense major histocompatibility complex class III
RT region and its comparison to mouse.";
RL Genome Res. 13:2621-2636(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=A;
CC IsoId=Q6UJB9-1; Sequence=Displayed;
CC Name=2; Synonyms=B;
CC IsoId=Q6UJB9-2; Sequence=VSP_028980;
CC -!- TISSUE SPECIFICITY: Testis. {ECO:0000269|PubMed:18398435}.
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DR EMBL; AY369079; AAQ67392.1; -; mRNA.
DR EMBL; AY369080; AAQ67393.1; -; mRNA.
DR EMBL; AK007170; BAB24883.1; -; mRNA.
DR EMBL; AC079938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC114542; AAI14543.1; -; mRNA.
DR CCDS; CCDS39313.1; -. [Q6UJB9-2]
DR CCDS; CCDS80423.1; -. [Q6UJB9-1]
DR RefSeq; NP_083957.1; NM_029681.3. [Q6UJB9-2]
DR RefSeq; NP_919041.1; NM_194065.3. [Q6UJB9-1]
DR AlphaFoldDB; Q6UJB9; -.
DR STRING; 10090.ENSMUSP00000045190; -.
DR PhosphoSitePlus; Q6UJB9; -.
DR PaxDb; Q6UJB9; -.
DR PRIDE; Q6UJB9; -.
DR ProteomicsDB; 259112; -. [Q6UJB9-1]
DR ProteomicsDB; 259113; -. [Q6UJB9-2]
DR Antibodypedia; 28566; 39 antibodies from 10 providers.
DR DNASU; 76629; -.
DR Ensembl; ENSMUST00000047305; ENSMUSP00000045190; ENSMUSG00000040576. [Q6UJB9-2]
DR Ensembl; ENSMUST00000201316; ENSMUSP00000144496; ENSMUSG00000040576. [Q6UJB9-1]
DR GeneID; 76629; -.
DR KEGG; mmu:76629; -.
DR UCSC; uc008zww.2; mouse. [Q6UJB9-1]
DR UCSC; uc008zwx.2; mouse. [Q6UJB9-2]
DR CTD; 135886; -.
DR MGI; MGI:1923879; Tmem270.
DR VEuPathDB; HostDB:ENSMUSG00000040576; -.
DR eggNOG; ENOG502T0K9; Eukaryota.
DR GeneTree; ENSGT00390000009243; -.
DR HOGENOM; CLU_114159_0_0_1; -.
DR InParanoid; Q6UJB9; -.
DR OMA; VTWTTCL; -.
DR OrthoDB; 1511708at2759; -.
DR PhylomeDB; Q6UJB9; -.
DR TreeFam; TF337697; -.
DR BioGRID-ORCS; 76629; 0 hits in 75 CRISPR screens.
DR PRO; PR:Q6UJB9; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q6UJB9; protein.
DR Bgee; ENSMUSG00000040576; Expressed in spermatid and 4 other tissues.
DR Genevisible; Q6UJB9; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029166; WBS28.
DR PANTHER; PTHR37369; PTHR37369; 1.
DR Pfam; PF15164; WBS28; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..264
FT /note="Transmembrane protein 270"
FT /id="PRO_0000308416"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 227..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 171..264
FT /note="NSVLLEAPALLRRLYLWVEHRTTLTSWNLAYLVTWTTCLASHLLQAAFEHTT
FT QLAQAQEVKSQETSGPPPQFLIPESSTTESGPLPPQPETPGE -> GWGRGSNLADLSH
FT PSSPYQCSCLAGPSCRILCCWKPRPC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072,
FT ECO:0000303|PubMed:18398435"
FT /id="VSP_028980"
SQ SEQUENCE 264 AA; 29547 MW; 5C1DFDAC64BFF49B CRC64;
MEAAPRVRSG LLRILLRAGR LSALLIQNRT HLYRFLLLKM AIFQHWVLGL AQEARGSGSD
QARQLPEVII TCALSLALRA GLTLLWVPMW LLLWGPRLAY RVGLCCTRTV RLALGHLCVC
EPLGLSPATF RDLFLSCLHS LMLVALLLLL LTWKLMQKAH HFSLGWLPSQ NSVLLEAPAL
LRRLYLWVEH RTTLTSWNLA YLVTWTTCLA SHLLQAAFEH TTQLAQAQEV KSQETSGPPP
QFLIPESSTT ESGPLPPQPE TPGE
