ID   TM271_HUMAN             Reviewed;         385 AA.
AC   A0A286YF58;
DT   28-MAR-2018, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2017, sequence version 1.
DT   03-AUG-2022, entry version 19.
DE   RecName: Full=Transmembrane protein 271 {ECO:0000305};
GN   Name=TMEM271 {ECO:0000312|HGNC:HGNC:53639};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
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DR   EMBL; AC116565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A286YF58; -.
DR   SMR; A0A286YF58; -.
DR   BioMuta; ENSG00000273238; -.
DR   MassIVE; A0A286YF58; -.
DR   PeptideAtlas; A0A286YF58; -.
DR   Ensembl; ENST00000610212.3; ENSP00000493161.1; ENSG00000273238.3.
DR   MANE-Select; ENST00000610212.3; ENSP00000493161.1; NM_001362796.2; NP_001349725.1.
DR   GeneCards; TMEM271; -.
DR   HGNC; HGNC:53639; TMEM271.
DR   HPA; ENSG00000273238; Tissue enriched (brain).
DR   neXtProt; NX_A0A286YF58; -.
DR   OpenTargets; ENSG00000273238; -.
DR   VEuPathDB; HostDB:ENSG00000273238; -.
DR   GeneTree; ENSGT00730000114722; -.
DR   OMA; ERKYSHY; -.
DR   Pharos; A0A286YF58; Tdark.
DR   PRO; PR:A0A286YF58; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   Bgee; ENSG00000273238; Expressed in superior frontal gyrus and 42 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..385
FT                   /note="Transmembrane protein 271"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5011637010"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          83..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          160..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          245..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        245..261
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   385 AA;  39128 MW;  7C91EE526502395C CRC64;
     MKWSVRGACA ALSSCLLLAC ALSAAAVGLK CFSLGSELRG EPFRLGAAAG AFYSGLLLAA
     GLSLLGAALL CCGPRDAPLA GSEPGPGLGV PAAPAGAPEA TPGESGAAAG APGPVSSQNL
     LLLGVLVFML GVLSAFAGAV IDGDTVSLVE RKYSHYCLPP RAPGSSPGSA PGSTPGSAPG
     SAPGSAPGSA PGAPRARSTL DSATSAKCRQ LKDYQRGLVL STVFNSLECL LGLLSLLLVK
     NYKSSQARRG RRGRRRGGRA LARPRGGSGL RAQPPASRAR RGRRGRRGRR LQQRPSEASI
     LSPEESDLAA PGDCAGFAAH HAVSYINVGV LHALDEAGAE VRCGGHPSVE LPGYAPSDPD
     LNASYPYCCR PPCETPRPWE THRAC