TM273_HUMAN
ID TM273_HUMAN Reviewed; 105 AA.
AC Q5T292; A6XND2; Q5T289; Q5T291;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Transmembrane protein 273 {ECO:0000305};
DE Flags: Precursor;
GN Name=TMEM273 {ECO:0000312|HGNC:HGNC:27274};
GN Synonyms=C10orf128 {ECO:0000312|HGNC:HGNC:27274};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Yu Z., Zheng Z., Tang T., Fu Y.;
RT "A computer system platform used to predict novel genes.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Neuroblastoma;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Hippocampus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q5T292-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5T292-2; Sequence=VSP_028715;
CC Name=3;
CC IsoId=Q5T292-3; Sequence=VSP_028716;
CC Name=4;
CC IsoId=Q5T292-4; Sequence=VSP_028717;
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DR EMBL; DQ884399; ABI63366.1; -; mRNA.
DR EMBL; AL524299; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC084727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL441885; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471187; EAW93107.1; -; Genomic_DNA.
DR EMBL; CH471187; EAW93108.1; -; Genomic_DNA.
DR EMBL; CH471187; EAW93110.1; -; Genomic_DNA.
DR EMBL; BC104438; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC104439; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BI544323; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS41519.1; -. [Q5T292-1]
DR CCDS; CCDS73128.1; -. [Q5T292-4]
DR RefSeq; NP_001010863.1; NM_001010863.2. [Q5T292-1]
DR RefSeq; NP_001275669.1; NM_001288740.1. [Q5T292-4]
DR RefSeq; NP_001275672.1; NM_001288743.1. [Q5T292-2]
DR AlphaFoldDB; Q5T292; -.
DR SMR; Q5T292; -.
DR STRING; 9606.ENSP00000363268; -.
DR iPTMnet; Q5T292; -.
DR PhosphoSitePlus; Q5T292; -.
DR BioMuta; C10orf128; -.
DR DMDM; 74744592; -.
DR MassIVE; Q5T292; -.
DR PaxDb; Q5T292; -.
DR PeptideAtlas; Q5T292; -.
DR PRIDE; Q5T292; -.
DR Antibodypedia; 49947; 5 antibodies from 5 providers.
DR DNASU; 170371; -.
DR Ensembl; ENST00000374148.1; ENSP00000363263.1; ENSG00000204161.14. [Q5T292-3]
DR Ensembl; ENST00000374153.7; ENSP00000363268.1; ENSG00000204161.14. [Q5T292-4]
DR Ensembl; ENST00000474718.5; ENSP00000417246.1; ENSG00000204161.14. [Q5T292-1]
DR GeneID; 170371; -.
DR KEGG; hsa:170371; -.
DR MANE-Select; ENST00000374153.7; ENSP00000363268.1; NM_001288740.3; NP_001275669.1. [Q5T292-4]
DR UCSC; uc001jhn.6; human. [Q5T292-1]
DR CTD; 170371; -.
DR GeneCards; TMEM273; -.
DR HGNC; HGNC:27274; TMEM273.
DR HPA; ENSG00000204161; Low tissue specificity.
DR neXtProt; NX_Q5T292; -.
DR OpenTargets; ENSG00000204161; -.
DR PharmGKB; PA134962893; -.
DR VEuPathDB; HostDB:ENSG00000204161; -.
DR eggNOG; ENOG502SWNF; Eukaryota.
DR GeneTree; ENSGT00390000000409; -.
DR HOGENOM; CLU_176398_0_0_1; -.
DR InParanoid; Q5T292; -.
DR OMA; QKRCTGD; -.
DR OrthoDB; 1313781at2759; -.
DR PhylomeDB; Q5T292; -.
DR TreeFam; TF354108; -.
DR PathwayCommons; Q5T292; -.
DR BioGRID-ORCS; 170371; 12 hits in 1068 CRISPR screens.
DR ChiTaRS; C10orf128; human.
DR GenomeRNAi; 170371; -.
DR Pharos; Q5T292; Tdark.
DR PRO; PR:Q5T292; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q5T292; protein.
DR Bgee; ENSG00000204161; Expressed in calcaneal tendon and 162 other tissues.
DR ExpressionAtlas; Q5T292; baseline and differential.
DR Genevisible; Q5T292; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029395; DUF4514.
DR PANTHER; PTHR37857; PTHR37857; 1.
DR Pfam; PF14986; DUF4514; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..105
FT /note="Transmembrane protein 273"
FT /id="PRO_0000307322"
FT TOPO_DOM 20..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..105
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VAR_SEQ 91..105
FT /note="RNHNFSKRDAQVIEL -> AHVLRDGPALGPLHLLFSVIGMLFARKLQASTL
FT FSFKSLLQCHHCIMEGLFKAKPQFLQKHLARSVQIHQLQKVKSFPKYAY (in
FT isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_028715"
FT VAR_SEQ 91..105
FT /note="RNHNFSKRDAQVIEL -> AHVLRDGPALGPLHLLFSVIGMLFARKLQASTL
FT FSFKSLLQCHHCIMEGLFKAKPQFLQKVSCKSDHLS (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028716"
FT VAR_SEQ 91..105
FT /note="RNHNFSKRDAQVIEL -> KLQASTLFSFKSLLQCHHCIMEGLFKAKPQFLQ
FT KRCTGD (in isoform 4)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_028717"
FT VARIANT 83
FT /note="P -> L (in dbSNP:rs12257132)"
FT /id="VAR_035409"
FT CONFLICT 16
FT /note="V -> A (in Ref. 5; BI544323)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 105 AA; 11325 MW; 31E0A590BAB765A7 CRC64;
MNLGVSMLRI LFLLDVGGAQ VLATGKTPGA EIDFKYALIG TAVGVAISAG FLALKICMIR
RHLFDDDSSD LKSTPGGLSD TIPLKKRAPR RNHNFSKRDA QVIEL
