ID   TM275_HUMAN             Reviewed;         177 AA.
AC   A0A0U1RQS6;
DT   13-FEB-2019, integrated into UniProtKB/Swiss-Prot.
DT   17-FEB-2016, sequence version 1.
DT   03-AUG-2022, entry version 29.
DE   RecName: Full=Transmembrane protein 275 {ECO:0000305};
GN   Name=TMEM275 {ECO:0000312|HGNC:HGNC:53938};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
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DR   EMBL; AL136373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF495930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS85971.1; -.
DR   AlphaFoldDB; A0A0U1RQS6; -.
DR   BioMuta; ENSG00000282881; -.
DR   MassIVE; A0A0U1RQS6; -.
DR   PeptideAtlas; A0A0U1RQS6; -.
DR   Ensembl; ENST00000634804.2; ENSP00000489149.1; ENSG00000282881.2.
DR   GeneCards; TMEM275; -.
DR   HGNC; HGNC:53938; TMEM275.
DR   HPA; ENSG00000282881; Tissue enriched (brain).
DR   neXtProt; NX_A0A0U1RQS6; -.
DR   OpenTargets; ENSG00000282881; -.
DR   VEuPathDB; HostDB:ENSG00000282881; -.
DR   GeneTree; ENSGT00390000008086; -.
DR   OMA; FFTACCV; -.
DR   PRO; PR:A0A0U1RQS6; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; A0A0U1RQS6; protein.
DR   Bgee; ENSG00000282881; Expressed in hypothalamus and 20 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..177
FT                   /note="Transmembrane protein 275"
FT                   /id="PRO_0000446326"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   177 AA;  17236 MW;  2D415F9F49E10947 CRC64;
     MPPAEKSEGP PVPAPAERAR GRVPGLPSPA LCCACGLCAL LAGVNVTLAG AFASFLPEHN
     ALLVVGLALL VLALGFFAAC CVCSRRGLAP RGRSAAAAGP GQGGGRAGPV ALEMESSEPT
     AQDTTAVQLS PAVSAASSGC SSPGPSPLAL EAPAPAAVCA LRSEGVQLNP PRARAAP