ID   TM2A_METMA              Reviewed;          12 AA.
AC   P80652;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   11-DEC-2019, entry version 54.
DE   RecName: Full=Alternative tetrahydromethanopterin S-methyltransferase 28 kDa subunit;
DE            EC=2.1.1.86;
DE   AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase 28 kDa subunit;
DE   Flags: Fragment;
OS   Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM
OS   11833 / OCM 88) (Methanosarcina frisia).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=192952;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88;
RX   PubMed=8774736; DOI=10.1111/j.1432-1033.1996.0857u.x;
RA   Lienard T., Becher B., Marschall M., Bowien S., Gottschalk G.;
RT   "Sodium ion translocation by N5-methyltetrahydromethanopterin: coenzyme M
RT   methyltransferase from Methanosarcina mazei Go1 reconstituted in ether
RT   lipid liposomes.";
RL   Eur. J. Biochem. 239:857-864(1996).
CC   -!- FUNCTION: This enzyme complex catalyzes an intermediate step in
CC       methanogenesis, the formation of methyl-coenzyme M and
CC       tetrahydromethanopterin from coenzyme M and N5-methyl-
CC       tetrahydromethanopterin.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2
CC         Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2
CC         Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101,
CC         ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286,
CC         ChEBI:CHEBI:58319; EC=2.1.1.86;
CC   -!- SUBUNIT: Composed of six different subunits.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cell membrane; Direct protein sequencing; Membrane; Methanogenesis;
KW   Methyltransferase; Transferase; Transmembrane.
FT   CHAIN           1..>12
FT                   /note="Alternative tetrahydromethanopterin S-
FT                   methyltransferase 28 kDa subunit"
FT                   /id="PRO_0000072568"
FT   NON_TER         12
SQ   SEQUENCE   12 AA;  1321 MW;  6DE4A5766232D76B CRC64;
     AEKLEPVLPL IV