ID   TM2D1_CAEEL             Reviewed;         210 AA.
AC   P61228;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=TM2 domain-containing protein C02F5.13;
DE   Flags: Precursor;
GN   ORFNames=C02F5.13;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-91, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RC   STRAIN=Bristol N2;
RX   PubMed=17761667; DOI=10.1074/mcp.m600392-mcp200;
RA   Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,
RA   Taoka M., Takahashi N., Isobe T.;
RT   "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis
RT   elegans and suggests an atypical translocation mechanism for integral
RT   membrane proteins.";
RL   Mol. Cell. Proteomics 6:2100-2109(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TM2 family. {ECO:0000305}.
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DR   EMBL; FO080288; CCD62638.1; -; Genomic_DNA.
DR   RefSeq; NP_001021138.1; NM_001025967.1.
DR   AlphaFoldDB; P61228; -.
DR   STRING; 6239.C02F5.13; -.
DR   iPTMnet; P61228; -.
DR   EPD; P61228; -.
DR   PaxDb; P61228; -.
DR   PeptideAtlas; P61228; -.
DR   EnsemblMetazoa; C02F5.13.1; C02F5.13.1; WBGene00015353.
DR   GeneID; 3565859; -.
DR   KEGG; cel:CELE_C02F5.13; -.
DR   UCSC; C02F5.13; c. elegans.
DR   CTD; 3565859; -.
DR   WormBase; C02F5.13; CE36093; WBGene00015353; -.
DR   eggNOG; KOG1486; Eukaryota.
DR   eggNOG; KOG4272; Eukaryota.
DR   GeneTree; ENSGT00730000111181; -.
DR   HOGENOM; CLU_084872_3_1_1; -.
DR   InParanoid; P61228; -.
DR   OMA; FLECKEP; -.
DR   OrthoDB; 1278556at2759; -.
DR   PhylomeDB; P61228; -.
DR   PRO; PR:P61228; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00015353; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007829; TM2.
DR   Pfam; PF05154; TM2; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..210
FT                   /note="TM2 domain-containing protein C02F5.13"
FT                   /id="PRO_0000065113"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        14
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        91
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:17761667"
SQ   SEQUENCE   210 AA;  23850 MW;  D8A372DB491300B7 CRC64;
     MRRLPWLIPF FLVNISNGNN EFRIEFEYPN NEKSEKCFDS SKENDLLDLF YVSTNPLGPV
     VECRFLENSF ILCEDPVPLY GPGQTGQQPA NESFRNEGKC LKMGGYRAED VEFTNVKCRV
     LPCIECHGPR TFTKSTPCII YNGHYFLTTL LYSIFLGVVA VDRFCLGYSA MAVGKLMTLG
     GFGIWWIVDI FLLVLGVLGP ADDSSWEPYY