TM2D1_DICDI
ID TM2D1_DICDI Reviewed; 153 AA.
AC Q9GPR3; Q54Z04;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=TM2 domain-containing protein DDB_G0277895;
GN ORFNames=DDB_G0277895;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=11222756; DOI=10.1093/nar/29.5.1068;
RA Rivero F., Dislich H., Gloeckner G., Noegel A.A.;
RT "The Dictyostelium discoideum family of Rho-related proteins.";
RL Nucleic Acids Res. 29:1068-1079(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TM2 family. {ECO:0000305}.
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DR EMBL; AF310895; AAG45137.1; -; Genomic_DNA.
DR EMBL; AAFI02000023; EAL68120.1; -; Genomic_DNA.
DR RefSeq; XP_642048.1; XM_636956.1.
DR AlphaFoldDB; Q9GPR3; -.
DR PaxDb; Q9GPR3; -.
DR EnsemblProtists; EAL68120; EAL68120; DDB_G0277895.
DR GeneID; 8621260; -.
DR KEGG; ddi:DDB_G0277895; -.
DR dictyBase; DDB_G0277895; -.
DR eggNOG; ENOG502RSR7; Eukaryota.
DR HOGENOM; CLU_1716643_0_0_1; -.
DR InParanoid; Q9GPR3; -.
DR OMA; WFIDICL; -.
DR PRO; PR:Q9GPR3; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR007829; TM2.
DR Pfam; PF05154; TM2; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..153
FT /note="TM2 domain-containing protein DDB_G0277895"
FT /id="PRO_0000330735"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 89..96
FT /note="1"
FT REPEAT 97..104
FT /note="2"
FT REPEAT 105..112
FT /note="3"
FT REPEAT 113..120
FT /note="4"
FT REPEAT 121..128
FT /note="5"
FT REPEAT 129..136
FT /note="6"
FT REGION 85..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..136
FT /note="6 X 8 AA tandem repeat of Q-Q-P-Y-G-A-P-P"
FT COMPBIAS 92..153
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 153 AA; 16871 MW; 0D0EEBFB529FA4F8 CRC64;
MSQKSVCVTY LLWLFFGLFG IHRFYLNRPC SGVLYLFTCG CFFIGWFIDI CLIPGMVEDY
NAKYDSMNKT TTTVTQVVVQ PVYQGSPQQQ PYGAPPQQPY GAPPQQPYGA PPQQPYGAPP
QQPYGAPPPQ PYGAPPPGAY APQGNYPPPY GPQ