ID   TM2D1_DICDI             Reviewed;         153 AA.
AC   Q9GPR3; Q54Z04;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=TM2 domain-containing protein DDB_G0277895;
GN   ORFNames=DDB_G0277895;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=11222756; DOI=10.1093/nar/29.5.1068;
RA   Rivero F., Dislich H., Gloeckner G., Noegel A.A.;
RT   "The Dictyostelium discoideum family of Rho-related proteins.";
RL   Nucleic Acids Res. 29:1068-1079(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TM2 family. {ECO:0000305}.
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DR   EMBL; AF310895; AAG45137.1; -; Genomic_DNA.
DR   EMBL; AAFI02000023; EAL68120.1; -; Genomic_DNA.
DR   RefSeq; XP_642048.1; XM_636956.1.
DR   AlphaFoldDB; Q9GPR3; -.
DR   PaxDb; Q9GPR3; -.
DR   EnsemblProtists; EAL68120; EAL68120; DDB_G0277895.
DR   GeneID; 8621260; -.
DR   KEGG; ddi:DDB_G0277895; -.
DR   dictyBase; DDB_G0277895; -.
DR   eggNOG; ENOG502RSR7; Eukaryota.
DR   HOGENOM; CLU_1716643_0_0_1; -.
DR   InParanoid; Q9GPR3; -.
DR   OMA; WFIDICL; -.
DR   PRO; PR:Q9GPR3; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007829; TM2.
DR   Pfam; PF05154; TM2; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..153
FT                   /note="TM2 domain-containing protein DDB_G0277895"
FT                   /id="PRO_0000330735"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          89..96
FT                   /note="1"
FT   REPEAT          97..104
FT                   /note="2"
FT   REPEAT          105..112
FT                   /note="3"
FT   REPEAT          113..120
FT                   /note="4"
FT   REPEAT          121..128
FT                   /note="5"
FT   REPEAT          129..136
FT                   /note="6"
FT   REGION          85..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          89..136
FT                   /note="6 X 8 AA tandem repeat of Q-Q-P-Y-G-A-P-P"
FT   COMPBIAS        92..153
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   153 AA;  16871 MW;  0D0EEBFB529FA4F8 CRC64;
     MSQKSVCVTY LLWLFFGLFG IHRFYLNRPC SGVLYLFTCG CFFIGWFIDI CLIPGMVEDY
     NAKYDSMNKT TTTVTQVVVQ PVYQGSPQQQ PYGAPPQQPY GAPPQQPYGA PPQQPYGAPP
     QQPYGAPPPQ PYGAPPPGAY APQGNYPPPY GPQ