ID   TM2D2_BOVIN             Reviewed;         214 AA.
AC   Q2TA35;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=TM2 domain-containing protein 2;
DE   Flags: Precursor;
GN   Name=TM2D2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TM2 family. {ECO:0000305}.
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DR   EMBL; BC111135; AAI11136.1; -; mRNA.
DR   RefSeq; NP_001033145.1; NM_001038056.2.
DR   AlphaFoldDB; Q2TA35; -.
DR   STRING; 9913.ENSBTAP00000004567; -.
DR   PaxDb; Q2TA35; -.
DR   PRIDE; Q2TA35; -.
DR   Ensembl; ENSBTAT00000004567; ENSBTAP00000004567; ENSBTAG00000003516.
DR   GeneID; 507906; -.
DR   KEGG; bta:507906; -.
DR   CTD; 83877; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003516; -.
DR   VGNC; VGNC:35901; TM2D2.
DR   eggNOG; KOG4272; Eukaryota.
DR   GeneTree; ENSGT00730000111181; -.
DR   HOGENOM; CLU_084872_3_0_1; -.
DR   InParanoid; Q2TA35; -.
DR   OMA; FLECKEP; -.
DR   OrthoDB; 1278556at2759; -.
DR   TreeFam; TF314896; -.
DR   Proteomes; UP000009136; Chromosome 27.
DR   Bgee; ENSBTAG00000003516; Expressed in rectus femoris and 109 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007829; TM2.
DR   Pfam; PF05154; TM2; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..214
FT                   /note="TM2 domain-containing protein 2"
FT                   /id="PRO_0000298981"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        92
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   214 AA;  23241 MW;  9C790ACE89001CDF CRC64;
     MVLGGYPVSY LLLCGQAALL LGNLLLLHCV SRSHSHNATA EPELTSAGAA HPEGSPGAAS
     WEYGDPHSPV ILCSYLPDEF IECEDPVDHV GNTTAFQELG YGCLKFGGQA YRDVEHTRVQ
     CRALDGIECA SPRTFLRENK PCIKYTGHYF ITTLLYSFFL GCFGVDRFCL GHTGTAVGKL
     LTLGGLGIWW FVDLILLITG GLMPSDGSNW CTIY