TM2D2_MOUSE
ID TM2D2_MOUSE Reviewed; 213 AA.
AC Q8R0I4; Q8BJJ1; Q9CWL9;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=TM2 domain-containing protein 2;
DE Flags: Precursor;
GN Name=Tm2d2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, Heart, Liver, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TM2 family. {ECO:0000305}.
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DR EMBL; AK045768; BAC32484.1; -; mRNA.
DR EMBL; AK083654; BAC38985.1; -; mRNA.
DR EMBL; AK085975; BAC39582.1; -; mRNA.
DR EMBL; AK010545; BAB27019.1; -; mRNA.
DR EMBL; AK149407; BAE28855.1; -; mRNA.
DR EMBL; AK166012; BAE38519.1; -; mRNA.
DR EMBL; AK160039; BAE35581.1; -; mRNA.
DR EMBL; BC026789; AAH26789.1; -; mRNA.
DR CCDS; CCDS22197.1; -.
DR RefSeq; NP_081470.2; NM_027194.3.
DR AlphaFoldDB; Q8R0I4; -.
DR STRING; 10090.ENSMUSP00000033961; -.
DR GlyGen; Q8R0I4; 1 site.
DR SwissPalm; Q8R0I4; -.
DR EPD; Q8R0I4; -.
DR MaxQB; Q8R0I4; -.
DR PaxDb; Q8R0I4; -.
DR PeptideAtlas; Q8R0I4; -.
DR PRIDE; Q8R0I4; -.
DR ProteomicsDB; 259561; -.
DR Antibodypedia; 56606; 33 antibodies from 10 providers.
DR Ensembl; ENSMUST00000033961; ENSMUSP00000033961; ENSMUSG00000031556.
DR GeneID; 69742; -.
DR KEGG; mmu:69742; -.
DR UCSC; uc009lfn.2; mouse.
DR CTD; 83877; -.
DR MGI; MGI:1916992; Tm2d2.
DR VEuPathDB; HostDB:ENSMUSG00000031556; -.
DR eggNOG; KOG4272; Eukaryota.
DR GeneTree; ENSGT00730000111181; -.
DR HOGENOM; CLU_084872_3_0_1; -.
DR InParanoid; Q8R0I4; -.
DR OMA; FLECKEP; -.
DR OrthoDB; 1278556at2759; -.
DR PhylomeDB; Q8R0I4; -.
DR TreeFam; TF314896; -.
DR BioGRID-ORCS; 69742; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Tm2d2; mouse.
DR PRO; PR:Q8R0I4; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8R0I4; protein.
DR Bgee; ENSMUSG00000031556; Expressed in spermatocyte and 255 other tissues.
DR ExpressionAtlas; Q8R0I4; baseline and differential.
DR Genevisible; Q8R0I4; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR007829; TM2.
DR Pfam; PF05154; TM2; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..213
FT /note="TM2 domain-containing protein 2"
FT /id="PRO_0000298983"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 91
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 22
FT /note="G -> W (in Ref. 1; BAB27019)"
FT /evidence="ECO:0000305"
FT CONFLICT 140
FT /note="P -> L (in Ref. 1; BAC38985)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 213 AA; 22853 MW; DA799904A704EFB3 CRC64;
MVLGGCPVSY LLLCGQAALL LGNLLLLHCV SRSHSFNATA ELDLTPSGAA HLEGPAASSW
EYSDPNSPVI LCSYLPDEFV DCDAPVDHVG NATASQELGY GCLKFGGQAY SDVQHTAVQC
RALEGIECAS PRTFLRENKP CIKYTGHYFI TTLLYSFFLG CFGVDRFCLG HTGTAVGKLL
TLGGLGIWWF VDLILLITGG LMPSDGSNWC TVY
