ID   TM2D2_PONAB             Reviewed;         214 AA.
AC   Q5RCC0;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=TM2 domain-containing protein 2;
DE   Flags: Precursor;
GN   Name=TM2D2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TM2 family. {ECO:0000305}.
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DR   EMBL; CR858354; CAH90587.1; -; mRNA.
DR   RefSeq; NP_001125316.1; NM_001131844.1.
DR   AlphaFoldDB; Q5RCC0; -.
DR   STRING; 9601.ENSPPYP00000020777; -.
DR   GeneID; 100172215; -.
DR   KEGG; pon:100172215; -.
DR   CTD; 83877; -.
DR   eggNOG; KOG4272; Eukaryota.
DR   InParanoid; Q5RCC0; -.
DR   OrthoDB; 1278556at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007829; TM2.
DR   Pfam; PF05154; TM2; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..214
FT                   /note="TM2 domain-containing protein 2"
FT                   /id="PRO_0000298984"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          40..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        92
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   214 AA;  22871 MW;  DF49261210671C59 CRC64;
     MVLGGCPVSY LLLCGQAALL LGNLLLLHCV SRSHSQNATA EPELTSAGAA QPEGPGAAAS
     WEYSDPHSPV ILCSYLPDEF IECEDPVDHV GNATASQELG YGCLKFGGQA YSDVEHTSVQ
     CHALAGIECA SPRTFLRENK PCIKYTGHYF ITTLLYSFFL GCFGVDRFCL GHTGTAVGKL
     LTLGGLGIWW FVDLILLITG GLMPSDGSNW CTVY