ID   TM2D2_RAT               Reviewed;         213 AA.
AC   Q566R2;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=TM2 domain-containing protein 2;
DE   Flags: Precursor;
GN   Name=Tm2d2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thymus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TM2 family. {ECO:0000305}.
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DR   EMBL; BC093382; AAH93382.1; -; mRNA.
DR   RefSeq; NP_001017444.1; NM_001017444.1.
DR   AlphaFoldDB; Q566R2; -.
DR   STRING; 10116.ENSRNOP00000022425; -.
DR   GlyGen; Q566R2; 1 site.
DR   PaxDb; Q566R2; -.
DR   PRIDE; Q566R2; -.
DR   Ensembl; ENSRNOT00000112655; ENSRNOP00000094884; ENSRNOG00000016559.
DR   GeneID; 290833; -.
DR   KEGG; rno:290833; -.
DR   UCSC; RGD:1306769; rat.
DR   CTD; 83877; -.
DR   RGD; 1306769; Tm2d2.
DR   eggNOG; KOG4272; Eukaryota.
DR   GeneTree; ENSGT00730000111181; -.
DR   HOGENOM; CLU_084872_3_0_1; -.
DR   InParanoid; Q566R2; -.
DR   OMA; FLECKEP; -.
DR   OrthoDB; 1278556at2759; -.
DR   PhylomeDB; Q566R2; -.
DR   TreeFam; TF314896; -.
DR   PRO; PR:Q566R2; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000016559; Expressed in quadriceps femoris and 20 other tissues.
DR   Genevisible; Q566R2; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007829; TM2.
DR   Pfam; PF05154; TM2; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..213
FT                   /note="TM2 domain-containing protein 2"
FT                   /id="PRO_0000298985"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        91
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   213 AA;  22929 MW;  2E983D18A16343C9 CRC64;
     MVLGGCPVSY LLLCGQAALL LGNLLLLHCV SRSHSFNATA ELDLTPSGAA HLEGPAASSW
     EYSDPNSPVI LCSYLPDEFV DCDAPVDHVG NATAYQELGY GCLKFGGQAY SDVEHTAVQC
     RALEGIECAS PRTFLRKNKP CIKYTGHYFI TTLLYSFFLG CFGVDRFCLG HTGTAVGKLL
     TLGGLGIWWF VDLILLITGG LMPSDGSNWC TVY