ID   TM2D2_XENLA             Reviewed;         198 AA.
AC   Q5XGR4;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 40.
DE   RecName: Full=TM2 domain-containing protein 2;
DE   Flags: Precursor;
GN   Name=tm2d2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TM2 family. {ECO:0000305}.
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DR   EMBL; BC084368; AAH84368.1; -; mRNA.
DR   RefSeq; NP_001088322.1; NM_001094853.1.
DR   AlphaFoldDB; Q5XGR4; -.
DR   GeneID; 495160; -.
DR   KEGG; xla:495160; -.
DR   CTD; 495160; -.
DR   Xenbase; XB-GENE-6078194; tm2d2.L.
DR   OrthoDB; 1278556at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 495160; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007829; TM2.
DR   Pfam; PF05154; TM2; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..198
FT                   /note="TM2 domain-containing protein 2"
FT                   /id="PRO_0000298987"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        29
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        40
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        76
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   198 AA;  21829 MW;  80CF423F0B1FE9ED CRC64;
     MRWPVPPLGY LLLGGQGLLL TFSLISSQNN TSPVTYPDIN VSAAPEPRDP LGPLVLCSYL
     PEEFVECDDP VDHMGNGTAQ QELRYGCKKF GGQAYGDVEH TQVMCRALDG IECDGSRSFL
     RGNRPCIKYT GHYFITTLLY SFFLGCFGVD RFCLGHTGTA VGKLLTWGGL GIWWFVDLIL
     LITGGLMPSD NSNWCTIY