ID   TM2D2_XENTR             Reviewed;         198 AA.
AC   Q5M8E3;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=TM2 domain-containing protein 2;
DE   Flags: Precursor;
GN   Name=tm2d2; ORFNames=TEgg137n19.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TM2 family. {ECO:0000305}.
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DR   EMBL; CR761327; CAJ81332.1; -; mRNA.
DR   EMBL; BC088075; AAH88075.1; -; mRNA.
DR   RefSeq; NP_001011324.1; NM_001011324.2.
DR   AlphaFoldDB; Q5M8E3; -.
DR   STRING; 8364.ENSXETP00000051937; -.
DR   PaxDb; Q5M8E3; -.
DR   DNASU; 496785; -.
DR   GeneID; 496785; -.
DR   KEGG; xtr:496785; -.
DR   CTD; 83877; -.
DR   Xenbase; XB-GENE-964283; tm2d2.
DR   eggNOG; KOG4272; Eukaryota.
DR   HOGENOM; CLU_084872_3_0_1; -.
DR   InParanoid; Q5M8E3; -.
DR   OMA; ECADPRI; -.
DR   OrthoDB; 1278556at2759; -.
DR   PhylomeDB; Q5M8E3; -.
DR   TreeFam; TF314896; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000015155; Expressed in egg cell and 13 other tissues.
DR   ExpressionAtlas; Q5M8E3; differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007829; TM2.
DR   Pfam; PF05154; TM2; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..198
FT                   /note="TM2 domain-containing protein 2"
FT                   /id="PRO_0000298988"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        29
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        40
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        76
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   198 AA;  21752 MW;  027F240B9657AB7D CRC64;
     MRWPVPPVGY LLLGGQGLLL TFSLISSQNQ TSPVTYPDLN LSAAPEPRDP LGPLVLCSYL
     PEEFVECDDP VDHMGNGTAQ QELRYGCKKF GGQAYGDVEH TQVMCRALDG IECDGPRSFL
     RGNKPCIKYT GHYFITTLLY SFFLGCFGVD RFCLGHTGTA VGKLLTLGGL GIWWFVDLIL
     LITGGLMPSD NSNWCTIY