TM2D3_HUMAN
ID TM2D3_HUMAN Reviewed; 247 AA.
AC Q9BRN9; B2RDK9; Q9H046; Q9H651;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=TM2 domain-containing protein 3;
DE AltName: Full=Beta-amyloid-binding protein-like protein 2;
DE Short=BBP-like protein 2;
DE Flags: Precursor;
GN Name=TM2D3; Synonyms=BLP2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY.
RX PubMed=11278849; DOI=10.1074/jbc.m011161200;
RA Kajkowski E.M., Lo C.F., Ning X., Walker S., Sofia H.J., Wang W., Edris W.,
RA Chanda P., Wagner E., Vile S., Ryan K., McHendry-Rinde B., Smith S.C.,
RA Wood A., Rhodes K.J., Kennedy J.D., Bard J., Jacobsen J.S.,
RA Ozenberger B.A.;
RT "Beta-amyloid peptide-induced apoptosis regulated by a novel protein
RT containing a G protein activation module.";
RL J. Biol. Chem. 276:18748-18756(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Placenta, and Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Colon, and Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 168-247.
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BRN9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BRN9-2; Sequence=VSP_027496;
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11278849}.
CC -!- SIMILARITY: Belongs to the TM2 family. {ECO:0000305}.
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DR EMBL; AF353992; AAK35066.1; -; mRNA.
DR EMBL; AK026257; BAB15415.1; -; mRNA.
DR EMBL; AK315584; BAG37956.1; -; mRNA.
DR EMBL; AC090164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471101; EAX02315.1; -; Genomic_DNA.
DR EMBL; BC006150; AAH06150.1; -; mRNA.
DR EMBL; BC008873; AAH08873.1; -; mRNA.
DR EMBL; AL512689; CAC21647.1; -; mRNA.
DR CCDS; CCDS10392.1; -. [Q9BRN9-2]
DR CCDS; CCDS10393.1; -. [Q9BRN9-1]
DR RefSeq; NP_079417.2; NM_025141.3. [Q9BRN9-2]
DR RefSeq; NP_510883.2; NM_078474.2. [Q9BRN9-1]
DR AlphaFoldDB; Q9BRN9; -.
DR BioGRID; 123181; 138.
DR IntAct; Q9BRN9; 27.
DR STRING; 9606.ENSP00000330433; -.
DR GlyConnect; 1814; 4 N-Linked glycans (4 sites).
DR GlyGen; Q9BRN9; 5 sites, 4 N-linked glycans (4 sites).
DR iPTMnet; Q9BRN9; -.
DR PhosphoSitePlus; Q9BRN9; -.
DR BioMuta; TM2D3; -.
DR DMDM; 308153510; -.
DR EPD; Q9BRN9; -.
DR jPOST; Q9BRN9; -.
DR MassIVE; Q9BRN9; -.
DR MaxQB; Q9BRN9; -.
DR PaxDb; Q9BRN9; -.
DR PeptideAtlas; Q9BRN9; -.
DR PRIDE; Q9BRN9; -.
DR ProteomicsDB; 78790; -. [Q9BRN9-1]
DR ProteomicsDB; 78791; -. [Q9BRN9-2]
DR Antibodypedia; 53600; 95 antibodies from 15 providers.
DR DNASU; 80213; -.
DR Ensembl; ENST00000333202.8; ENSP00000330433.3; ENSG00000184277.13. [Q9BRN9-1]
DR Ensembl; ENST00000347970.7; ENSP00000327584.3; ENSG00000184277.13. [Q9BRN9-2]
DR GeneID; 80213; -.
DR KEGG; hsa:80213; -.
DR MANE-Select; ENST00000333202.8; ENSP00000330433.3; NM_078474.3; NP_510883.2.
DR UCSC; uc002bxi.4; human. [Q9BRN9-1]
DR CTD; 80213; -.
DR DisGeNET; 80213; -.
DR GeneCards; TM2D3; -.
DR HGNC; HGNC:24128; TM2D3.
DR HPA; ENSG00000184277; Low tissue specificity.
DR MIM; 610014; gene.
DR neXtProt; NX_Q9BRN9; -.
DR OpenTargets; ENSG00000184277; -.
DR PharmGKB; PA142670800; -.
DR VEuPathDB; HostDB:ENSG00000184277; -.
DR eggNOG; KOG4272; Eukaryota.
DR GeneTree; ENSGT00940000158389; -.
DR InParanoid; Q9BRN9; -.
DR OMA; QIWRPDR; -.
DR OrthoDB; 1385397at2759; -.
DR PhylomeDB; Q9BRN9; -.
DR TreeFam; TF314896; -.
DR PathwayCommons; Q9BRN9; -.
DR SignaLink; Q9BRN9; -.
DR BioGRID-ORCS; 80213; 50 hits in 1084 CRISPR screens.
DR GenomeRNAi; 80213; -.
DR Pharos; Q9BRN9; Tbio.
DR PRO; PR:Q9BRN9; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q9BRN9; protein.
DR Bgee; ENSG00000184277; Expressed in secondary oocyte and 200 other tissues.
DR ExpressionAtlas; Q9BRN9; baseline and differential.
DR Genevisible; Q9BRN9; HS.
DR GO; GO:0044214; C:spanning component of plasma membrane; ISM:FlyBase.
DR GO; GO:0046331; P:lateral inhibition; IGI:FlyBase.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; ISS:FlyBase.
DR InterPro; IPR007829; TM2.
DR Pfam; PF05154; TM2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..247
FT /note="TM2 domain-containing protein 3"
FT /id="PRO_0000298989"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 140
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 31..56
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11278849,
FT ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:15489334"
FT /id="VSP_027496"
FT CONFLICT 6
FT /note="L -> R (in Ref. 1; AAK35066, 2; BAB15415/BAG37956,
FT 4; EAX02315 and 5; AAH06150/AAH08873)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 247 AA; 27118 MW; 9E18F6F1E50E41E7 CRC64;
MAGGVLPLRG LRALCRVLLF LSQFCILSGG EQSQALAQSI KDPGPTRTFT VVPRAAESTE
IPPYVMKCPS NGLCSRLPAD CIDCTTNFSC TYGKPVTFDC AVKPSVTCVD QDFKSQKNFI
INMTCRFCWQ LPETDYECTN STSCMTVSCP RQRYPANCTV RDHVHCLGNR TFPKMLYCNW
TGGYKWSTAL ALSITLGGFG ADRFYLGQWR EGLGKLFSFG GLGIWTLIDV LLIGVGYVGP
ADGSLYI
