TM2D3_MOUSE
ID TM2D3_MOUSE Reviewed; 261 AA.
AC Q8BJ83; Q9D156;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=TM2 domain-containing protein 3;
DE Flags: Precursor;
GN Name=Tm2d3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Forelimb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BJ83-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BJ83-2; Sequence=VSP_027497;
CC -!- SIMILARITY: Belongs to the TM2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK003917; BAB23075.1; -; mRNA.
DR EMBL; AK077858; BAC37037.1; -; mRNA.
DR EMBL; BC024620; AAH24620.1; -; mRNA.
DR CCDS; CCDS21340.1; -. [Q8BJ83-2]
DR CCDS; CCDS21341.1; -. [Q8BJ83-1]
DR RefSeq; NP_081071.1; NM_026795.3. [Q8BJ83-2]
DR RefSeq; NP_835157.1; NM_178056.3. [Q8BJ83-1]
DR AlphaFoldDB; Q8BJ83; -.
DR GlyConnect; 2771; 7 N-Linked glycans (2 sites).
DR GlyGen; Q8BJ83; 2 sites, 7 N-linked glycans (2 sites).
DR PhosphoSitePlus; Q8BJ83; -.
DR MaxQB; Q8BJ83; -.
DR PaxDb; Q8BJ83; -.
DR PRIDE; Q8BJ83; -.
DR ProteomicsDB; 259562; -. [Q8BJ83-1]
DR ProteomicsDB; 259563; -. [Q8BJ83-2]
DR Antibodypedia; 53600; 95 antibodies from 15 providers.
DR DNASU; 68634; -.
DR Ensembl; ENSMUST00000032726; ENSMUSP00000032726; ENSMUSG00000078681. [Q8BJ83-2]
DR Ensembl; ENSMUST00000065574; ENSMUSP00000064967; ENSMUSG00000078681. [Q8BJ83-1]
DR Ensembl; ENSMUST00000107495; ENSMUSP00000103119; ENSMUSG00000078681. [Q8BJ83-1]
DR GeneID; 68634; -.
DR KEGG; mmu:68634; -.
DR UCSC; uc009hgu.2; mouse. [Q8BJ83-2]
DR UCSC; uc012fms.1; mouse. [Q8BJ83-1]
DR CTD; 80213; -.
DR MGI; MGI:1915884; Tm2d3.
DR VEuPathDB; HostDB:ENSMUSG00000078681; -.
DR GeneTree; ENSGT00940000158389; -.
DR HOGENOM; CLU_084872_1_0_1; -.
DR InParanoid; Q8BJ83; -.
DR OMA; QIWRPDR; -.
DR OrthoDB; 1385397at2759; -.
DR PhylomeDB; Q8BJ83; -.
DR TreeFam; TF314896; -.
DR BioGRID-ORCS; 68634; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Tm2d3; mouse.
DR PRO; PR:Q8BJ83; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BJ83; protein.
DR Bgee; ENSMUSG00000078681; Expressed in animal zygote and 250 other tissues.
DR ExpressionAtlas; Q8BJ83; baseline and differential.
DR Genevisible; Q8BJ83; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046331; P:lateral inhibition; ISO:MGI.
DR InterPro; IPR007829; TM2.
DR Pfam; PF05154; TM2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..44
FT /evidence="ECO:0000255"
FT CHAIN 45..261
FT /note="TM2 domain-containing protein 3"
FT /id="PRO_0000298990"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 101
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 31..61
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_027497"
SQ SEQUENCE 261 AA; 28880 MW; 70346780D3CF5CDB CRC64;
MEAAAEPLRS VRHLSRVLLF LSQCYILSGD GSLNLEHSQP LAQAIKDPGP TRTFSVVPRA
AENQLFSHLT ESTEIPPYMT KCPSNGLCSR LPADCIECAT NVSCTYGKPV TFDCTVKPSV
TCVDQDLKPQ RNFVINMTCR FCWQLPETDY ECSNSTTCMT VACPRQRYFA NCTVRDHIHC
LGNRTFPKLL YCNWTGGYKW STALALSITL GGFGADRFYL GQWREGLGKL FSFGGLGIWT
LIDVLLIGVG YVGPADGSLY I
