ID   TM2D4_CAEEL             Reviewed;         409 AA.
AC   Q94421;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 2.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=TM2 domain-containing protein ZK858.5;
GN   ORFNames=ZK858.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TM2 family. {ECO:0000305}.
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DR   EMBL; Z79759; CAB02140.2; -; Genomic_DNA.
DR   PIR; T28057; T28057.
DR   RefSeq; NP_492450.2; NM_060049.2.
DR   AlphaFoldDB; Q94421; -.
DR   STRING; 6239.ZK858.5; -.
DR   EPD; Q94421; -.
DR   PaxDb; Q94421; -.
DR   PeptideAtlas; Q94421; -.
DR   EnsemblMetazoa; ZK858.5.1; ZK858.5.1; WBGene00014118.
DR   GeneID; 172738; -.
DR   KEGG; cel:CELE_ZK858.5; -.
DR   UCSC; ZK858.5; c. elegans.
DR   CTD; 172738; -.
DR   WormBase; ZK858.5; CE34235; WBGene00014118; -.
DR   eggNOG; ENOG502SRYM; Eukaryota.
DR   HOGENOM; CLU_041057_0_0_1; -.
DR   InParanoid; Q94421; -.
DR   OMA; WRNYLIH; -.
DR   OrthoDB; 1087358at2759; -.
DR   PRO; PR:Q94421; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00014118; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007829; TM2.
DR   Pfam; PF05154; TM2; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..409
FT                   /note="TM2 domain-containing protein ZK858.5"
FT                   /id="PRO_0000298996"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        69
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        195
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        294
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   409 AA;  47180 MW;  5B28B72926A2FB12 CRC64;
     MNNEETEVKP WIVRIILIVG GLFGAHRLYL KQVPEAFVFF STLGVLLIGW LYDSFMFKYE
     VNEYNQLINQ SENNKEKEKW KNGKMQASQS KFVDFSFTRF LYSVLYGSYI GLATWLACTV
     TFGWTDINLI PFICVVALGI TAGIYIIGQC GGQSRELSYI WMASFSSMFI MVRLAQTTVF
     RAIFLTAIVS TVIGNRSARL KKRRHTWKHF LFWSSLFLML VCVILLGCSR KVADKQVTAT
     RPGTFRETIS VGSLIRDRIF DAKKVHSFFE GNPIIEYHSK SDIKNKNGEK TLKNSSFWYQ
     VWSGELFDEL TGAAHLTKID WIELTTTFIV DVLRSEARVI DGSSTIEPFK WALWRNYLIH
     RFSLDPLISD DRLRTECKKW QTEEKSKKGN VDRDYNILAA KQGCSTFLL